Splenomegaly

«Splenomegaly is an enlargement of the spleen[1]. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cell affecting granulocytes, erythrocyte or platelets in any combination; a compensatory proliferative response in the bone marrow; and the potential for correction of these abnormalities by splenectomy. Splenomegaly is usually associated with increased workload (such as in hemolytic anemia), which suggests that it is a response to hyperfunction. It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cell being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemia and lymphoma. Thus, the finding of an enlarged spleen, along with caput medusae, is an important sign of portal hypertension.[2]» (wikipedia)

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