Weight gain editSet type / Edit

«Weight gain is an increase in body weight. This can involve an increase in muscle mass, fat deposits, excess fluids such as water or other factors. Weight gain can be a symptom of a serious medical condition.» (wikipedia)

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Summary on Weight gain

Biochemistry
May increase: BMI
Decreases: Lifespan, Running economy, Running technique, VO2max
Symptoms
Causes or may cause: Diabetes Type 2, Insulin resistance, Obesity
Causes
Increased or caused by: Diabetes Type 2, Insulin resistance, Noise-induced sleep disruption, Sleep Disorders
May be increased or caused by: Hypothyroidism
Prevention
Cured by: Liraglutide
May be decreased by: Black Cumin Oil, Gilbert's syndrome
BioLinks
Indirect BioLinks
Related Proofs

  • 2016 Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials

  • «RESULTS: After analyzing 23 articles including 1531 participants, these results were achieved: In 4 trials, N. sativa reduced BP, but in 5 trials it could not. Fasting blood sugar (FBS) was reduced significantly in 13 studies. In addition, N. sativa reduced levels of glycosylated hemoglobin (HbA1c). Although weight and waist circumference (WC) in 2 articles were reduced significantly, in 6 articles they were not. Fluctuation in lipid profile in the articles was very controversial, being significant in many of them but not in others.

    CONCLUSION: Our systematic review revealed that N. sativa supplementation might be effective in glycemic control in humans.»

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122217/ 10.4103/1735-1995.175154

  • 2017 Running Technique is an Important Component of Running Economy and Performance

  • «Numerous kinematic variables were correlated with RE and performance (LEc, 19 variables; SB time, 11 variables). Regression analysis found three variables (pelvis vertical oscillation during ground contact normalized to height, minimum knee joint angle during ground contact, and minimum horizontal pelvis velocity) explained 39% of LEc variability. In addition, four variables (minimum horizontal pelvis velocity, shank touchdown angle, duty factor, and trunk forward lean) combined to explain 31% of the variability in performance (SB time).»

  • Proof: Class C. Non-randomised Trial (CT), Pilot Research
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473370/ 10.1249/MSS.0000000000001245
  • Magnitude: +Strong

  • 2018 Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats

  • «RESULTS: The body weight of the STZ-induced diabetic group rats reduced significantly (P < 0.05) than did those of the control nondiabetic rats at the 3rd and 4th weeks of the experiment. However, NSO 2 mL/kg treatment of diabetic rats increased their body weight (P < 0.05) compared to those of diabetic nontreated rats at the 4th week of the experimental period (Table 1).

    CONCLUSION: Based on the current results, NSO was found to be an effective protection against the adverse consequences of STZ-induced diabetes in Wistar rats. NSO exerts its effect through thymoquinone antioxidant potential, which improved pancreatic and hepatic integrity, thus increasing pancreatic islet immunoreactivity, therefore increasing the serum insulin level, increasing hepatic glycogen content, reducing the elevated blood glucose level, and counteracting diabetic dyslipidemia.»

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857299/ 10.1155/2018/8104165

  • 2011 Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus.

  • «CONCLUSION: the results of this study indicate that a dose of 2 gm/ day of Nigella sativa might be a beneficial adjuvant to oral hypoglycemic agents in type 2 diabetic patients.»

  • https://www.ncbi.nlm.nih.gov/pubmed/21675032 PMID:21675032

  • 2013 Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.

  • After age and gender matching, GS subjects showed a trend towards lower BMI than the respective controls (P = 0.075).

  • Comments:
    After age and gender matching, GS subjects showed a trend towards lower BMI than the respective controls (P = 0.075).
  • https://www.ncbi.nlm.nih.gov/pubmed/23566065 10.1042/CS20120661

  • 2013 Gilbert's syndrome and the risk of death: a population-based cohort study.

  • «RESULTS: During the 350 000 PYs of follow up across the Gilbert's and comparison cohorts, there were 1174 deaths. Mortality rates were 24/10 000 PYs in the Gilbert's cohort versus 50/10 000 PYs in the comparison cohort. Mortality rates were around half in patients with Gilbert's syndrome after accounting for sociodemographics and general health indicators (adjusted mortality rate ratio: 0.5 [95% confidence interval; 0.4-0.7; P < 0.001]).

    CONCLUSIONS: Mortality rates observed for people with Gilbert's syndrome in the general population are almost half those of people without evidence of Gilbert's syndrome.»

  • https://www.ncbi.nlm.nih.gov/pubmed/23701650 10.1111/jgh.12279

  • 2015 Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert's syndrome?

  • Bilirubin appears to reduce circulating lipids, in addition to being associated with reducedriskoftype2diabetes[39,77].

  • https://www.ncbi.nlm.nih.gov/pubmed/25576848 10.1016/j.atherosclerosis.2014.12.042

  • 2017 Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.

  • The results presented highlight the potential of bilirubin metabolism in contributing to the prevention of overweight/
    obesity, particularly during aging. In our study, 25% of GS subjects, compared to 46% in the HCG were overweight/obese. In the older subgroup (mean age: 52 yrs), these figures increased to 35% and
    69%, respectively. Data analysis revealed significantly lower abdominal obesity in GS compared to the HCG, indicated by a smaller HC and WC, remarkably in the older group.

    The GS group had higher serum UCB (30.7 ± 11.4 vs. 8.7 ± 3.6, p < .001), lower BMI (8%, p < 0.001) and HC (4%, p <0 .01) compared to the HCG. 25% of GS and 46% of the HCG were overweight/obese (p <0 .01). Further biologically relevant yet non-significant differences in WC, abdominal circumference (AC), WHR and the FM were found between the groups

  • https://www.ncbi.nlm.nih.gov/pubmed/29279144 10.1016/j.atherosclerosis.2017.12.021

  • 2018 Noise-induced sleep disruption increases weight gain and decreases energy metabolism in female rats.

  • «Noise exposure significantly increased weight gain and food intake compared to females that slept undisturbed. Noise also significantly increased wakefulness, reduced sleep and resulted in rebound sleep during the recovery period. Total energy expenditure was significantly lower during both noise exposure and recovery due to lower energy expenditure during spontaneous physical activity and sleep. Notably, noise did not alter the estrous cycle length.

    As previously observed in male rats, noise exposure disrupted sleep and increased weight gain in females but did not alter the length of the estrous cycle. This is the first demonstration of weight gain in female rats during sleep disruption. We conclude that the sleep disruption caused by exposure to environmental noise is a significant tool for determining how sleep loss contributes to obesity in females.»

  • https://www.ncbi.nlm.nih.gov/pubmed/30568267 10.1038/s41366-018-0293-9

Modified: 9 months ago on Jan 8, 2019
personEvgeniya Malysheva 2 lvl added it 9 months ago on Jan 8, 2019.
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