DNA damage symptom

«DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome[1]. In human cell, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.[2] Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cell after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs).[3][4] This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis.

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Pathways of DNA damage

Textual paths of Biolinks with Validity Score > 3.0
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This tool shows paths like: A B C DNA damage


Visualisation of logical biolinks between drugs, supplements, symptoms etc..