BBR Berberine supplement
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«Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinolinealkaloids found in such plants as Berberis (e.g. Berberis vulgaris – barberry, Berberis aristata – tree turmeric, Mahonia aquifolium – Oregon-grape, Hydrastis canadensis – goldenseal, Xanthorhiza simplicissima – yellowroot, Phellodendron amurense[2] – Amur cork tree, Coptis chinensis – Chinese goldthread, Tinospora cordifolia, Argemone mexicana – prickly poppy, and Eschscholzia californica – Californian poppy). Berberine is usually found in the roots, rhizomes, stems, and bark.[citation needed]

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Summary on Berberine

BBR is also known as BBR and it is a supplement. Here is an overview of its 63 biolinks with acceptable average validity.
↑ Increases: AMPK, Autophagy, HDL, IL-10, P53, SIRT1
↑ May increase: AMPK, Fur density, Lifespan
↓ Decreases: CASP1, CCL11, CD4+ T-cells, Cholesterol, Cholesterol, Clostridium difficile, COX-2, CRP, ERK, Glucose, HbA1C, Helicobacter pylori, IFN-γ, IKK, IL-17A, IL-1β, IL-21, IL-23, IL-23, IL-6, IL-8, Intestinal peristalsis, LDL, MMP-2, MMP-9, MMP-9, NF-kB, NLRP3, NLRP3, P65, PGE2, PPARγ, STAT3, TGFβ, Th17, TNF-α, Triglycerides
↓ May decrease: Anxiety, CRP, IGF1 Receptor, MMP-2, MMP-9
↑ Improves or cures: Dyslipidemia, Ethanol-induced oxidative stress, Insulin resistance, Insulin sensitivity, Psoriasis
↑ May improve: Chronic Inflammation, Colorectal cancer, Senescent cells
↑ Causes: α-adrenergic receptors
→ Increased by: Barberry, Coptis chinensis
→ May be increased by: Phellodendron bark extracts

Pathways of Berberine

Textual paths of Biolinks with Validity Score > 3.0
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Evidence Sources

Biolinks for Berberine are extracted by users from 45 related publications.
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