N-Acetylcysteine
NAC
metabolite
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«Acetylcysteine, also known as N-acetylcysteine (NAC), is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease.[1] It can be taken intravenously, by mouth, or inhaled as a mist.[1] Some people use it as a dietary supplement.[6][7]
Common side effects include nausea and vomiting when taken by mouth.[1] The skin may occasionally become red and itchy with either form.[1] A non-immune type of anaphylaxis may also occur.[1] It appears to be safe in pregnancy.[1] For paracetamol overdose, it works by increasing the level of glutathione, an antioxidant that can neutralise the toxic breakdown products of paracetamol.[1] When inhaled, it acts as a mucolytic by decreasing the thickness of mucus.[8]
Acetylcysteine was initially patented in 1960 and licensed for use in 1968.[9] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[10] It is available as a generic medication and is inexpensive.[11]» (wikipedia)
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Evidence Sources
Biolinks for NAC are extracted by users from 9 related publications.-
2014Meta-Analysis
- Organism: Humans
- Strong Magnitude of Effect.
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2017Systematic Review
- Organism: Humans
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2019Meta-Analysis
- Organism: Humans
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2014
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2016
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