Nonsteroidal Anti-Inflammatory Drug
«Nonsteroidal anti-inflammatory drug (NSAID) are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation. Side effects depend on the specific drug, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack and kidney disease.
The term nonsteroidal distinguishes these drugs from steroids, which while having a similar eicosanoid-depressing, anti-inflammatory action, have a broad range of other effects. First used in 1960, the term served to distance these medications from steroids.
NSAID work by inhibiting the activity of cyclooxygenase enzymes (COX-1 and/or COX-2). In cell, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandin which are involved in inflammation, and thromboxanes which are involved in blood clotting.
There are two types of NSAID available: non-selective and COX-2 selective. Most NSAID are non-selective, and inhibit the activity of both COX-1 and COX-2. These NSAID, while reducing inflammation, also thin the blood (especially aspirin) and increase the risk of gastrointestinal ulcers/bleeds. COX-2 selective inhibitors have less gastrointestinal side effects, but promote thrombosis and substantially increase the risk of heart attack. As a result, COX-2 selective inhibitors are generally contraindicated due to the high risk of undiagnosed vascular disease. These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. By inhibiting physiological COX activity, all NSAID increase the risk of kidney disease and, through a related mechanism, heart attack.
The most prominent NSAID are aspirin, ibuprofen and naproxen, all available over the counter in most countries.Paracetamol (acetaminophen) is generally not considered an NSAID because it has only little anti-inflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body.» (wikipedia)
Do something with NSAID, already
This screen hints what BioMindmap can do with medical objects
- See 16 Biolinks that connect NSAID with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to NSAID
- There are 10 Evidences supporting 16 NSAID Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- NSAID Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of NSAID. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Instream into nodes that connect into NSAID.
- Outstream from nodes that go out from NSAID.
- Promoters of NSAID
- Add biolink i.e. «X increases NSAID». Intuitively easy.
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