Angiotensin Receptor Blockers
ARB
metabolite
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«Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonist, AT1 receptor antagonists or sartan, are a group of pharmaceuticals that modulate the renin–angiotensin system. Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. They block the activation of AT1 receptors, preventing the binding of angiotensin II.» (wikipedia)
Summary on ARB
Angiotensin Receptor Blockers is
also known as Angiotensin II receptor blocker and it is
a
metabolite.
Here is an overview of its
20 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
ARBS:
Candesartan, Losartan, Telmisartan, Valsartan
↓ Decreases:
Atherosclerosis, CRP, Inflammation, Oxidative stress, VCAM-1
↓ May decrease:
Blood pressure, Coenzyme Q10
↑ Improves or cures:
Cardiovascular Diseases, Diabetes Type 2
→ May be increased with an increase of cofactors:
Statins
? Affects:
ACE inhibitors
? Affected by:
ACE inhibitors, Statins
× Does not affect:
Covid-19 mortality
Pathways of ARB
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C ARB
Evidence Sources
Biolinks for ARB are extracted by users from 8 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (ARB) are listed here. Abstracts are hidden.
- Organism: Humans
-
2007Publications Review
- Strong Magnitude of Effect.
-
-
2020Cohort
- Organism: Humans
-
-
2011
-
-
2006
-
-
2013
-
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Biolink is a statement and objects connection.
- See 20 Biolinks that connect ARB with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to ARB
Biolinks should be proven by researches.
- There are 8 Evidences supporting 20 ARB Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
X
→
B
→
C
→
ARB. can be generated from biolinks.
Visualise biolinks!
- ARB Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of ARB. and Subnodes: .
- Find Path to another object.
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ARB has 7 incoming and 13 outgoing biolinks:
- Instream into nodes that connect into ARB.
- Outstream from nodes that go out from ARB.
- Promoters of ARB
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases ARB». Intuitively easy.
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