Glucose Generation
Gluconeogenesis
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«Gluconeogenesis (GNG) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. From breakdown of proteins, these substrates include glucogenic amino acids (although not ketogenic amino acids); from breakdown of lipids (such as triglycerides), they include glycerol, odd-chain fatty acids (although not even-chain fatty acids, see below); and from other steps in metabolism they include pyruvate and lactate.
Gluconeogenesis is one of several main mechanisms used by humans and many other animals to maintain blood glucose levels, avoiding low levels (hypoglycemia). Other means include the degradation of glycogen (glycogenolysis)[1] and fatty acid catabolism.
Gluconeogenesis is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms.[2] In vertebrates, gluconeogenesis takes place mainly in the liver and, to a lesser extent, in the cortex of the kidney. In ruminants, this tends to be a continuous process.[3] In many other animals, the process occurs during periods of fasting, starvation, low-carbohydrate diet, or intense exercise. The process is highly endergonic until it is coupled to the hydrolysis of ATP or GTP, effectively making the process exergonic. For example, the pathway leading from pyruvate to glucose-6-phosphate requires 4 molecules of ATP and 2 molecules of GTP to proceed spontaneously. Gluconeogenesis is often associated with ketosis. Gluconeogenesis is also a target of therapy for type 2 diabetes, such as the antidiabetic drug, metformin, which inhibits glucose formation and stimulates glucose uptake by cell.[4] In ruminants, because dietary carbohydrate tend to be metabolized by rumen organisms, gluconeogenesis occurs regardless of fasting, low-carbohydrate diet, exercise, etc.[5]» (wikipedia)
Summary on Gluconeogenesis
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Pathways of Gluconeogenesis
Evidence Sources
Biolinks for Gluconeogenesis are extracted by users from 7 related publications.-
2020Publications Review
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2012Rodents
- Organism: Mouse / Rat (Rodents)
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2014Systematic Review
- Organism: Humans — Not Healthy
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1999
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2001
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2013Non Random CT
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2018
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