Prostaglandin E2
PGE2
metabolite
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«Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication.[1] As a medication it is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open.[1][2] In babies it is used in those with congenital heart defect until surgery can be carried out.[2] It may be used within the vagina or by injection into a vein.[1][3]
Common side effects include vomiting, fever, diarrhea, and excessive uterine contraction.[1] In babies there may be decreased breathing and low blood pressure.[2] Care should be taken in people with asthma or glaucoma and it is not recommended in those who have had a prior C-section.[4] Prostaglandin E2 is in the oxytocics family of medications. It works by binding and activating the prostaglandin E2 receptor which results in the opening and softening of the cervix and dilation of blood vessels.[1][2]
Prostaglandin E2 was first made in 1970 and approved for medical use in the United States in 1977.[2][1] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] In the United Kingdom a dose costs the NHS about 8.50 to 30.00 pounds.[3][6] In the United States a course of treatment costs more than US$200.[4] Prostaglandin E2 works as well as prostaglandin E1 in babies; however, it is much less expensive.[2]» (wikipedia)
Summary on PGE2
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Evidence Sources
Biolinks for PGE2 are extracted by users from 16 related publications.-
2008Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2012Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2016Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2017Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2020Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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1997Cohort
- Organism: Humans
- Notable Magnitude of Effect.
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2013Rodents
- Condition: «mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice»
- Organism: Mouse / Rat (Rodents)
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2015
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2006Systematic Review
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2011
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2016
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2018
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1998
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