Linoleic Acid is a polyunsaturated essential fatty acid found mostly in plant oils. It is used in the biosynthesis of prostaglandin and cell membranes. Linoleic acid is a doubly unsaturated fatty acid, also known as an omega-6 fatty acid, occurring widely in plant glycosides. PUFA. Don't mix with Alpha Lipoic Acid.
«Los Angeles (/lɔːsˈændʒələs/ (listen); Spanish: Los Ángeles),[a] officially the City of Los Angeles and known colloquially by its initials L.A., is the most populous city in California and the second most populous city in the United States, after New York City. With an estimated population of four million, Los Angeles is the cultural, financial, and commercial center of Southern California. Nicknamed the "City of Angels" partly because of its name's Spanish meaning, Los Angeles is known for its Mediterranean climate, ethnic diversity, Hollywood and the entertainment industry, and sprawling metropolis.
Los Angeles is located in a large basin bounded by the Pacific Ocean on one side and by mountains as high as 10,000 feet (3,000 m) on the others. The city proper, which covers about 469 square miles (1,210 km2), is the seat of Los Angeles County, the most populated county in the country. Los Angeles is the principal city of the Los Angeles metropolitan area; with a population of 13.1 million residents it is the second largest in the United States after that of New York City. It is part of the Los Angeles-Long Beachcombined statistical area, also the second most populous in the nation with a 2015 estimated population of 18.7 million.
Los Angeles is one of the most substantial economic engines within the United States, with a diverse economy in a broad range of professional and cultural fields. Los Angeles is also famous as the home of Hollywood, a major center of the world entertainment industry. A global city, it has been ranked 6th in the Global Cities Index and 9th in the Global Economic Power Index. The Los Angeles combined statistical area also has a gross metropolitan product of $831 billion (as of 2008[update]), making it the third-largest in the world, after the Tokyo and New York metropolitan areas. Los Angeles hosted the 1932 and 1984 Summer Olympics and will host the event for a third time in 2028. The city also hosted the Miss Universe pageant twice, in 1990 and 2006, and was one of 9 American cities to host the 1994 FIFA men's soccer World Cup and one of 8 to host the 1999 FIFA women's soccer World Cup, hosting the finalmatch for both tournaments.
Historically home to the Chumash and Tongva, Los Angeles was claimed by Juan Rodríguez Cabrillo for Spain in 1542 along with the rest of what would become Alta California. The city was officially founded on September 4, 1781, by Spanish governor Felipe de Neve. It became a part of Mexico in 1821 following the Mexican War of Independence. In 1848, at the end of the Mexican–American War, Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo, becoming part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood. The discovery of oil in the 1890s brought rapid growth to the city. The completion of the Los Angeles Aqueduct in 1913, delivering water from Eastern California, later assured the city's continued rapid growth.
The Los Angeles coastal area was settled by the Tongva (Gabrieleños) and Chumashtribes. A Gabrieleño settlement in the area was called iyáangẚ (written Yang-na by the Spanish), meaning "poison oak place".
Maritime explorer Juan Rodríguez Cabrillo claimed the area of southern California for the Spanish Empire in 1542 while on an official military exploring expedition moving north along the Pacific coast from earlier colonizing bases of New Spain in Central and South America.Gaspar de Portolà and Franciscan missionary Juan Crespí, reached the present site of Los Angeles on August 2, 1769.
In 1771, Franciscan friar Junípero Serra directed the building of the Mission San Gabriel Arcángel, the first mission in the area. On September 4, 1781, a group of forty-four settlers known as "Los Pobladores" founded the pueblo they called El Pueblo de Nuestra Señora la Reina de los Ángeles, 'The Town of Our Lady the Queen of the Angels'.[b] The present-day city has the largest Roman CatholicArchdiocese in the United States. Two-thirds of the settlers were mestizo or mulatto with a mixture of African, indigenous and European ancestry. The settlement remained a small ranch town for decades, but by 1820, the population had increased to about 650 residents. Today, the pueblo is commemorated in the historic district of Los Angeles Pueblo Plaza and Olvera Street, the oldest part of Los Angeles.
New Spain achieved its independence from the Spanish Empire in 1821, and the pueblo continued as a part of Mexico. During Mexican rule, Governor Pío Pico made Los Angeles Alta California's regional capital.
Mexican rule ended during the Mexican–American War: Americans took control from the Californios after a series of battles, culminating with the signing of the Treaty of Cahuenga on January 13, 1847.
Railroads arrived with the completion of the transcontinental Southern Pacific line to Los Angeles in 1876 and the Santa Fe Railroad in 1885.Petroleum was discovered in the city and surrounding area in 1892, and by 1923, the discoveries had helped California become the country's largest oil producer, accounting for about one-quarter of the world's petroleum output.
By 1900, the population had grown to more than 102,000, putting pressure on the city's water supply. The completion of the Los Angeles Aqueduct in 1913, under the supervision of William Mulholland, assured the continued growth of the city. Due to clauses in the city's charter that effectively prevented the City of Los Angeles from selling or providing water from the aqueduct to any area outside its borders, many adjacent city and communities became compelled to annex themselves into Los Angeles.
Los Angeles created the first municipal zoning ordinance in the United States. On September 14, 1908, the Los Angeles City Council promulgated residential and industrial land use zones. The new ordinance established three residential zones of a single type, where industrial uses were prohibited. The proscriptions included barns, lumber yards, and any industrial land use employing machine-powered equipment. These laws were enforced against industrial properties after-the-fact. These prohibitions were in addition to existing activities which were already regulated as nuisances. These included explosives warehousing, gas works, oil-drilling, slaughterhouses, and tanneries. Los Angeles City Council also designated seven industrial zones within the city. However, between 1908 and 1915, Los Angeles City Council created various exceptions to the broad proscriptions which applied to these three residential zones, and as a consequence, some industrial uses emerged within them. There are two differences from the 1908 Residence District Ordinance and later zoning laws in the United States. First, the 1908 laws did not establish a comprehensive zoning map as the 1916 New York City Zoning Ordinance did. Second, the residential zones did not distinguish types of housing: it treated apartments, hotels, and detached-single-family housing equally.» (wikipedia)
Do something with LA, already
This screen hints what BioMindmap can do with medical objects
- See 16 Biolinks that connect LA with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to LA
- There are 10 Evidences supporting 16 LA Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- LA Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of LA. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Add biolink i.e. «X increases LA». Intuitively easy.
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
- Ask Telegram Bot to get quick Summary on any object.