NO
Nitric Oxide
compound
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My Medkit
My Symptoms
My Goals
«Nitric oxide is a colorless gas with the formula NO. Nitric oxide is a free radical, i.e., it has an unpaired electron. In mammals, including humans, nitric oxide is a signaling molecule in many physiological and pathological processes. It was proclaimed the "Molecule of the Year" in 1992. The 1998 Nobel Prize in Physiology or Medicine was awarded for discovering nitric oxide's role as a cardiovascular signalling molecule.
Nitric oxide should not be confused with nitrous oxide (N2O), an anesthetic, or with nitrogen dioxide (NO2), a brown toxic gas and a major air pollutant.» (wikipedia)
Summary on Nitric Oxide
NO is
also known as nitrogen oxide and it is
a
compound.
Here is an overview of its
57 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
↑ May increase:
Angiogenesis, Blood flow, FGF2, MAPK, Sperm motility, Vasodilation
↓ Decreases:
GnRH, Coronavirus 2019
↓ May decrease:
CcOX
↑ May improve:
Erectile function
Sources of NO
→ Increased by:
ACE inhibitors, Arginine, Beetroot, Blue Light, Butyrate, Citrulline, Endurance Exercise, Exercise, Fasting, Humming, iNOS, L-Arginine, Melatonin, Nitrates, Nitroglycerin, NOS, Omega-3 + Vitamin E, Proinflammatory cytokines, PUFA, Red light, Taiji, Taurine, Testosterone
→ May be increased by:
Blueberry, Hypoxia, L-theanine, NIR, Pentoxifylline, Selenium + Vitamin E, SOD, Sunlight, Tadalafil, Viagra
→ May be increased with an increase of cofactors:
Vitamin C
↘ Decreased by:
Apigenin, Beta alanine, Bromelain, Chamomile, DIM, Fisetin, Metformin, Sauerkraut + Selenium
↘ May be decreased by:
ASU, Cytotoxicity, L-lysine, Mouthwash, Selenium + Vitamin E
Pathways of Nitric Oxide
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C NO
Evidence Sources
Biolinks for Nitric Oxide are extracted by users from 60 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (Nitric Oxide) are listed here. Abstracts are hidden.
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2002
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2003Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2006
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2007Publications Review
- Strong Magnitude of Effect.
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2008Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2013Rodents
- Dose: Rats in control group (Con) were given tap water, and rats in the other two groups were given water containing 1% taurine (taurine group, Tau) and 1% b -alanine ( b -alanine group, b -Ala).
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2016Publications Review
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2017Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2018Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2019RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2020Systematic Review
- Organism: Humans
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2017RCT
- Organism: Humans
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2020Non-human Cells
- Organism: In vitro
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1999Non-human Cells
- Condition: in macrofages
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2020Clinical Guideline
- Organism: Humans
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2009Rodents
- Organism: Mouse / Rat (Rodents)
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2010Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2011
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2012
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2013
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2013Rodents
- Condition: «mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice»
- Organism: Mouse / Rat (Rodents)
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2014Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2015Systematic Review
- Organism: Humans
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2015
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2016Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2015
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2017
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2017
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2017Publications Review
- Strong Magnitude of Effect.
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2017Rodents
- Organism: Mouse / Rat (Rodents)
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2017Rodents
- Organism: Mouse / Rat (Rodents)
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2020Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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2020Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2000
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2001
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2001
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2001
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2001
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2001
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2003Human Cells
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2003
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2004
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2004Human Cells
- Organism: In vitro
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2005Human Cells
- Organism: In vitro
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2013
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2014Human Cells
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2015
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2016
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2017Human Cells
- Condition: PF enhances nitric oxide production in human spermatozoa
- Organism: In vivo
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2018
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2018
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2018
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2018Non Random CT
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2019
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2019Rodents
- Condition: in semen
- Organism: Mouse / Rat (Rodents)
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1994
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Biolink is a statement and objects connection.
- See 57 Biolinks that connect NO with other objects
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Biolinks should be proven by researches.
- There are 60 Evidences supporting 57 NO Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
NO. can be generated from biolinks.
Visualise biolinks!
- NO Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
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NO has 47 incoming and 10 outgoing biolinks:
When you read PubMed research organise your findings here.
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