Gonadotropin-Releasing Hormone
GnRH
hormone
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My Symptoms
My Goals
«Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropicpeptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.» (wikipedia)
Summary on GnRH
Gonadotropin-Releasing Hormone is
also known as LHRH, Luteinizing hormone-releasing hormone, Luteinizing Hormone-Releasing Factor (LRF), GnRH agonists and it is
a
hormone.
Here is an overview of its
32 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
↑ May increase:
Testosterone
↓ Decreases:
Antimüllerian Hormone
↓ May decrease:
Testosterone
↑ May improve:
PMS
→ Increased by:
Glutamate, Kisspeptin, Leptin, Leptin, MAPK, Pregnenolone sulfate, Taurine
→ May be increased by:
Degarelix
↘ Decreased by:
Allopregnanolone, Estradiol, Fasting, GABA, Ghrelin, GnIH, Melatonin, NF-kB, Nitric Oxide, Progesterone
× Is not affected by:
Antimüllerian Hormone, Beta alanine
Pathways of GnRH
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C GnRH
Add Biolink
GnRH Biolinks
-
-1.2Perhaps, GnRH inhibits Testosterone(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for GnRH are extracted by users from 25 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (GnRH) are listed here. Abstracts are hidden.
- Organism: Humans
-
2004Meta-Analysis
- Condition: Premenstrual Dysphoric Disorder
- Organism: Females — Premenopausal
- Strong Magnitude of Effect.
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-
2006Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
-
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2008Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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2012RCT
- Condition: ewes (sheeps)
- Organism: Mammals
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-
2013Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
-
-
2013Publications Review
- Organism: Humans
- Strong Magnitude of Effect.
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2017Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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-
2018Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2019RCT
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2020Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2021Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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-
2021Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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1984Rodents
- Dose: The daily dose of 100 ng melatonin in saline was chosen because it was shown to maximally inhibit the different parameters studied
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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-
1995Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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-
2010Publications Review
- Organism: Mammals
- Notable Magnitude of Effect.
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-
2013Rodents
- Organism: Mouse / Rat (Rodents)
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-
2015
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2019Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2005
-
-
2008
-
- From this research we know that
-
-1.2Perhaps, GnRH inhibits Testosterone(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
-
2018
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2018Systematic Review
- Organism: Humans
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2018
- Organism: Humans
-
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2019Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
-
See extended map
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Map GnRH to ...
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Do something with GnRH
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 32 Biolinks that connect GnRH with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to GnRH
Biolinks should be proven by researches.
- There are 25 Evidences supporting 32 GnRH Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
GnRH. can be generated from biolinks.
Visualise biolinks!
- GnRH Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of GnRH. and Subnodes: .
- Find Path to another object.
- Build Custom Map
GnRH has 24 incoming and 8 outgoing biolinks:
- Instream into nodes that connect into GnRH.
- Outstream from nodes that go out from GnRH.
- Promoters of GnRH
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases GnRH». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
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