Gonadotropin-Inhibitory Hormone GnIH peptide

«Gonadotropin-inhibitory hormone (GnIH) is a RFamide-related peptide coded by the NPVF gene in mammals.» «GnIH binds to the Gαi protein coupled receptor GPR147 to suppress adenylyl cyclase formation of cAMP and inhibit protein kinase cascades affecting gene expression. GnIH inhibits the same signaling pathway that GnRH activates to promote follicle stimulating hormone (FSH) and luteinizing hormone (LH) expression.[12][13] The compound RF9 is a known GPR147 receptor antagonist.» (wikipedia)

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Pathways of GnIH

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Pavel Solodkin ranked added it 1 year ago on Oct 25, 2021