Gonadotropin-Inhibitory Hormone
GnIH
peptide
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«Gonadotropin-inhibitory hormone (GnIH) is a RFamide-related peptide coded by the NPVF gene in mammals.» «GnIH binds to the Gαi protein coupled receptor GPR147 to suppress adenylyl cyclase formation of cAMP and inhibit protein kinase cascades affecting gene expression. GnIH inhibits the same signaling pathway that GnRH activates to promote follicle stimulating hormone (FSH) and luteinizing hormone (LH) expression.[12][13] The compound RF9 is a known GPR147 receptor antagonist.» (wikipedia)
Summary on GnIH
Gonadotropin-Inhibitory Hormone is
a
peptide.
Our overview of this peptide is quite short so far, as we are still gathering information.
Bolder font means better proofs.
Alt+click opens node.
↓ Decreases:
Adenylyl cyclase, FSH, GnRH, LH
→ Increased by:
Melatonin
Pathways of GnIH
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C GnIH
Evidence Sources
Biolinks for GnIH are extracted by users from 3 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (GnIH) are listed here. Abstracts are hidden.
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2012RCT
- Condition: ewes (sheeps)
- Organism: Mammals
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2013Publications Review
- Organism: Humans
- Strong Magnitude of Effect.
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2005Non-human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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Map GnIH to ...
NB! This is beta feature, which sometimes hangs. We are working on optimising it.
Pavel Solodkin
ranked
added it
1 year ago
on Oct 25, 2021
Do something with GnIH
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 5 Biolinks that connect GnIH with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to GnIH
Biolinks should be proven by researches.
- There are 3 Evidences supporting 5 GnIH Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
GnIH. can be generated from biolinks.
Visualise biolinks!
- GnIH Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of GnIH. and Subnodes: .
- Find Path to another object.
- Build Custom Map
GnIH has 1 incoming and 4 outgoing biolinks:
- Instream into nodes that connect into GnIH.
- Outstream from nodes that go out from GnIH.
- Promoters of GnIH
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases GnIH». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
Other options
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