Interleukin 6
IL-6
cytokine
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My Medkit
My Symptoms
My Goals
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My Medkit
My Symptoms
My Goals
«Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.[5]
In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cell in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.» (wikipedia)
Summary on IL-6
Interleukin 6 is
also known as IL6 and it is
a
cytokine.
Here is an overview of its
52 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
It is:
is type of Adipokines
↑ May increase:
CRP, Myocardial Infarction
→ May be increased by:
Adipose tissue, Adipose tissue macrophage, Alcohol, Exercise, HIIT, Leptin, Osteocalcin, Resistance training, UV damage
Lowering of IL-6
↘ Decreased by:
Anthocyanins, Baicalein, Black Cumin Oil, Cold water immersion, Contrast water therapy, Coenzyme Q10, Cryotherapy, Vitamin D3, Ghrelin, Gilbert's Syndrome, Massage, Metformin, MICT, Omega-3, Pentoxifylline, PUFA, Yoga
↘ May be decreased by:
3,3'-diindolylemethane, Aspirin, ASU, ASU, Diosmin, Hydrogen-rich water, Laquinimod, Lion's Mane, Magnesium, Myricetin, Panax Ginseng, Sulforaphane, Young plasma
? Affects:
Frailty
× Is not affected by:
Coenzyme Q10, Hesperidin, Niacin, Omega-3, Testosterone
Pathways of IL-6
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C IL-6
Evidence Sources
Biolinks for IL-6 are extracted by users from 48 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (IL-6) are listed here. Abstracts are hidden.
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2014RCT
- Organism: Humans
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2014Meta-Analysis
- Organism: Humans
- Strong Magnitude of Effect.
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2015RCT
- Organism: Humans
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2018RCT
- Condition: in older men with low testosterone
- Organism: Humans
- Minor Magnitude of Effect.
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2019Meta-Analysis
- Organism: Humans
- Notable Magnitude of Effect.
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2020Rodents
- Dose: Daily oral administration of laquinimod (25 mg/kg) or 3,3'-diindolylmethane (250 mg/kg) from
- Organism: Mouse / Rat (Rodents)
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2020Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2007Human Cells
- Organism: In vitro
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2003Rodents
- Organism: Mouse / Rat (Rodents)
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2013
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2013Rodents
- Condition: «mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice»
- Organism: Mouse / Rat (Rodents)
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2016
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2018Meta-Analysis
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2018Cohort
- Organism: Humans
- Notable Magnitude of Effect.
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2017RCT
- Organism: Humans — Not Healthy
- Notable Magnitude of Effect.
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2018
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2019
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1999
- Organism: In vitro
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2000Expert Opinion
- Organism: Humans
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2003Human Cells
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2006RCT
- Dose: 1500 mg
- Condition: Metabolic syndrome
- Organism: Humans
- Notable Magnitude of Effect.
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2006Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2010
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2013
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2013
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2015
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2015RCT
- Organism: Humans — Not Healthy
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2015
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2016
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2017
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2017Human Cells
- Organism: In vitro
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2017
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2017
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2017
- Organism: Humans
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2017
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2018Rodents
- Organism: Mouse / Rat (Rodents)
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2018Systematic Review
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2018RCT
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2019Systematic Review
- Organism: Humans
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2019RCT
- Organism: Humans
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2020RCT
- Organism: Humans
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2020RCT
- Dose: 2000 iu daily
- Condition: migraine
- Organism: Humans
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2020RCT
- Condition: patients with chronic kidney disease in hemodialysis
- Organism: Humans
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2020RCT
- Organism: Humans — Not Healthy
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1998
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2017Systematic Review
- Organism: Mixed Organisms
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This screen hints what BioMindmap can do with medical objects
Biolink is a statement and objects connection.
- See 52 Biolinks that connect IL-6 with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to IL-6
Biolinks should be proven by researches.
- There are 48 Evidences supporting 52 IL-6 Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
IL-6. can be generated from biolinks.
Visualise biolinks!
- IL-6 Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of IL-6. and Subnodes: .
- Find Path to another object.
- Build Custom Map
IL-6 has 48 incoming and 4 outgoing biolinks:
- Instream into nodes that connect into IL-6.
- Outstream from nodes that go out from IL-6.
- Promoters of IL-6
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases IL-6». Intuitively easy.
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