IL-6 • How it works? Researched 92 times | BioMindmap.com

Interleukin 6 IL-6 cytokine

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«Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.[5]

In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cell in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.» (wikipedia)

Interleukin 6 is also known as IL6 and it is a cytokine. Here is an overview of its with

Classification

Bolder font means better proofs. Alt+click opens node.

It is: ,

Biochemistry

↑ Increases: , , ,

↑ May increase: ,

↓ Decreases: ,

Effects

↑ Causes:

↑ May cause:

Sources of IL-6

→ Increased by: , , , , , , , , , ,

→ May be increased by: , , , , , , , , ,

Lowering of IL-6

↘ Decreased by: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

↘ May be decreased by: , , , , , , , , , , , , ,

Correlation

? Affects: ,

? Affected by: , ,

Absence of Correlation

× Is not affected by: , , , ,

Pathways of IL-6

Textual paths of Biolinks with Validity Score > 3.0

How to increase IL-6?

How to decrease IL-6?

What IL-6 increases or causes?

What IL-6 decreases?

Paths that connect IL-6 with other objects (coming soon)?

Uses in-app credits

This tool shows paths like: A B C IL-6

Mindmaps

Visualisation of logical biolinks between drugs, supplements, symptoms etc..

IL-6 Biolinks

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Obviously IL-6 is Proinflammatory cytokine
—
Obviously IL-6 is type of Adipokines
9.9
IL-6 increases Platelets
9.7
Astaxanthin decreases IL-6
+10
9.6
Fisetin decreases IL-6
9.5
Depression increases IL-6
9.5
PUFA decreases IL-6
9.2
Berberine decreases IL-6
+6
7.2
IL-6 inhibits Treg cells
7.0
Apigenin decreases IL-6
7.0
EGCG decreases IL-6
7.0
IL-6 promotes Th17
6.7
Melatonin decreases IL-6
6.5
Baicalein inhibits IL-6
6.2
Endometriosis positively correlates with IL-6
5.3
IL-6 stimulates Thrombopoietin
5.2
Contrast water therapy decreases IL-6
5.2
Cold water immersion decreases IL-6
5.2
Cryotherapy decreases IL-6
5.2
Massage decreases IL-6
5.1
IL-6 activates STAT3
5.0
Psoriasis positively correlates with IL-6
5.0
Hesperidin does not improve IL-6
5.0
IL-1β increases IL-6
5.0
Gilbert's Syndrome decreases IL-6
4.3
Leptin may increase IL-6
4.2
Ghrelin inhibits IL-6
4.1
Metformin decreases IL-6
3.7
Panax Ginseng may decrease IL-6
(BioMindmap Proof Quality is Acceptable.)
3.5
Strength exercise increases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.5
MICT decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.5
HIIT increases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.3
Testosterone inhibits IL-6
(BioMindmap Proof Quality is Acceptable.)
3.3
Omega-3 lowers IL-6
(BioMindmap Proof Quality is Acceptable.)
3.3
Black Cumin Oil decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.3
Vitamin D3 reduces IL-6
(BioMindmap Proof Quality is Acceptable.)
3.3
Vitamin D increases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.2
TLR4 increases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.2
Chamomile decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.1
Niacin does not affect IL-6
(BioMindmap Proof Quality is Acceptable.)
3.1
Omega-3 does not affect IL-6
(BioMindmap Proof Quality is Acceptable.)
3.0
Yoga decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
3.0
Anthocyanins decrease IL-6
(BioMindmap Proof Quality is Acceptable.)
3.0
Pentoxifylline lowers IL-6
(BioMindmap Proof Quality is Acceptable.)
2.9
Bromantane decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
2.9
Testosterone does not affect IL-6
(BioMindmap Proof Quality is Acceptable.)
2.8
Estradiol decreases IL-6
(BioMindmap Proof Quality is Acceptable.)
2.5
ACE2 upregulates IL-6
(BioMindmap Proof Quality is Acceptable.)
2.5
Coenzyme Q10 lowers IL-6
(BioMindmap Proof Quality is Acceptable.)
2.4
Progesterone increases IL-6
(BioMindmap Proof Quality is Low.)
2.4
IL-6 decreases DHT
(BioMindmap Proof Quality is Low.)
2.4
Doxycycline upregulates IL-6
(BioMindmap Proof Quality is Low.)
2.4
Hashimoto Thyroiditis positively correlates with IL-6
(BioMindmap Proof Quality is Low.)
2.2
IFN-α increases IL-6
(BioMindmap Proof Quality is Low.)
2.2
Vitamin K1 decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
Glycine + NAC decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
Bromelain decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
I3C decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
DIM decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
L. casei decreases IL-6
(BioMindmap Proof Quality is Low.)
2.1
LDN decreases IL-6
(BioMindmap Proof Quality is Low.)
2.1
IL-6 is a biomarker of Endometriosis
(BioMindmap Proof Quality is Low.)
2.1
AGEs correlated with increased IL-6
(BioMindmap Proof Quality is Low.)
2.0
IL-6 regulates Th17
(BioMindmap Proof Quality is Low.)
2.0
Sulforaphane lowers IL-6
(BioMindmap Proof Quality is Low.)
1.9
Glucose increases IL-6
(BioMindmap Proof Quality is Low.)
1.9
LDN increases IL-6
(BioMindmap Proof Quality is Low.)
1.9
Phytol decreases IL-6
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases IL-6
(BioMindmap Proof Quality is Low.)
1.9
IL-6 associated with Frailty
(BioMindmap Proof Quality is Low.)
1.9
Hydrogen-rich water decreases IL-6
(BioMindmap Proof Quality is Low.)
1.8
Alcohol increases IL-6
(BioMindmap Proof Quality is Low.)
1.8
Coenzyme Q10 does not affect IL-6
(BioMindmap Proof Quality is Low.)
1.8
IL-6 induces CRP
(BioMindmap Proof Quality is Low.)
1.8
UV damage increases IL-6
(BioMindmap Proof Quality is Low.)
1.7
Myricetin inhibits IL-6
(BioMindmap Proof Quality is Low.)
1.6
Diosmin lowers IL-6
(BioMindmap Proof Quality is Low.)
1.4
Laquinimod inhibits IL-6
(BioMindmap Proof Quality is Low.)
1.4
3,3'-diindolylemethane inhibits IL-6
(BioMindmap Proof Quality is Low.)
1.4
Adipose tissue macrophage produces IL-6
(BioMindmap Proof Quality is Low.)
1.4
ASU inhibits IL-6
(BioMindmap Proof Quality is Low.)
1.1
IL-6 may cause Chronic Obstructive Pulmonary Disease
(BioMindmap Proof Quality is Low.)
1.1
ASU downregulates IL-6
(BioMindmap Proof Quality is Low.)
0.9
Lion's Mane may decrease IL-6
(BioMindmap Proof Quality is Very Light.)
0.8
Perhaps, Exercise transiently increase IL-6
(Not proven by a research!)
0.8
Perhaps, HIIT transiently increase IL-6
(Not proven by a research!)
0.8
Perhaps, Osteocalcin increases IL-6
(Not proven by a research!)
0.7
IL-6 may increase Myocardial Infarction
(BioMindmap Proof Quality is Very Light.)
-0.4
Perhaps, Adipose tissue secretes IL-6
(BioMindmap had flagged this statement.)
-0.6
Perhaps, Aspirin may reduce IL-6
(Not proven by a research!)
-1.9
Perhaps, Magnesium may reduce IL-6
(BioMindmap Proof Quality is Negative.)
-2.0
Perhaps, Young plasma may decrease IL-6
(BioMindmap Proof Quality is Negative.)

Evidence Sources

Biolinks for IL-6 are extracted by users from 134 related publications.