Tumorigenesis process

«Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cell are transformed into cancer cell. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by disrupting the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cell by natural selection in the body. Only certain mutations lead to cancer whereas the majority of mutations do not.

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Pathways of Tumorigenesis

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