Matrix Metalloproteinase 2
MMP-2
metabolite
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«72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2gene.[5] The MMP2 gene is located on chromosome 16 at position 12.2.[6]» (wikipedia)
Summary on MMP-2
Matrix Metalloproteinase 2 is
a
metabolite.
Here is an overview of its
22 biolinks
with
low
average validity.
Bolder font means better proofs.
Alt+click opens node.
It is:
MMP
↑ May increase:
Angiostatin
↓ Decreases:
Fibroblast differentiation
→ Increased by:
Influenza H3N2 virus, Lung injury
↘ Decreased by:
Apigenin, Astaxanthin, Berberine, DIM, Doxycycline, Fisetin, Fisetin, Ginger
↘ May be decreased by:
Angiostatin, Aspirin, Berberine, Fisetin, Glutathione, Lutein
× Is not affected by:
Fisetin
Pathways of MMP-2
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C MMP-2
Evidence Sources
Biolinks for MMP-2 are extracted by users from 21 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (MMP-2) are listed here. Abstracts are hidden.
-
2010Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2011Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2011Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2012Rodents
- Dose: DOX (20 mg/kg or 60 mg/kg) was dissolved in water, and administered orally using a metal gavage
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2013Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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-
2016Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2017Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
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2019Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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-
2021Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2000
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2013
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2014
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2015
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2020Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2012
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2012
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2017
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2018
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Do something with MMP-2
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Biolink is a statement and objects connection.
- See 22 Biolinks that connect MMP-2 with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to MMP-2
Biolinks should be proven by researches.
- There are 21 Evidences supporting 22 MMP-2 Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
MMP-2. can be generated from biolinks.
Visualise biolinks!
- MMP-2 Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of MMP-2. and Subnodes: .
- Find Path to another object.
- Build Custom Map
MMP-2 has 19 incoming and 3 outgoing biolinks:
- Instream into nodes that connect into MMP-2.
- Outstream from nodes that go out from MMP-2.
- Promoters of MMP-2
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases MMP-2». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
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