Interferon Type I
Type I IFN
protein
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My Goals
«Human type I interferon (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system.
Interferon bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains.
Type I IFNs are found in all mammals, and homologous (similar) molecules have been found in birds, reptiles, amphibians and fish species.» (wikipedia)
Summary on Type I IFN
Interferon Type I is
a
protein.
Our overview of this protein is quite short so far, as we are still gathering information.
Bolder font means better proofs.
Alt+click opens node.
↑ Increases:
STAT1
↑ May increase:
IL-10
↓ Decreases:
IL-1
↓ May decrease:
IL-1β
→ Increased by:
Macrophages, NF-kB
Pathways of Type I IFN
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C Type I IFN
Evidence Sources
Biolinks for Type I IFN are extracted by users from 4 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (Type I IFN) are listed here. Abstracts are hidden.
-
2000Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2011Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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2014Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2014Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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See extended map
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Map Type I IFN to ...
NB! This is beta feature, which sometimes hangs. We are working on optimising it.
Pavel Solodkin
ranked
added it
11 months ago
on Jun 4, 2021
Do something with Type I IFN
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 8 Biolinks that connect Type I IFN with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Type I IFN
Biolinks should be proven by researches.
- There are 4 Evidences supporting 8 Type I IFN Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
Type I IFN. can be generated from biolinks.
Visualise biolinks!
- Type I IFN Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Type I IFN. and Subnodes: .
- Find Path to another object.
- Build Custom Map
Type I IFN has 4 incoming and 4 outgoing biolinks:
- Instream into nodes that connect into Type I IFN.
- Outstream from nodes that go out from Type I IFN.
- Promoters of Type I IFN
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases Type I IFN». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
Other options
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