Interferon Type I
Type I IFN
protein
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My Goals
«Human type I interferon (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system.
Interferon bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains.
Type I IFNs are found in all mammals, and homologous (similar) molecules have been found in birds, reptiles, amphibians and fish species.» (wikipedia)
Summary on Type I IFN
Interferon Type I is
a
protein.
Our overview of this protein is quite short so far, as we are still gathering information.
Bolder font means better proofs.
Alt+click opens node.
↑ Increases:
STAT1
↑ May increase:
IL-10
↓ Decreases:
IL-1
↓ May decrease:
IL-1β
→ Increased by:
Macrophages, NF-kB
Pathways of Type I IFN
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C Type I IFN
Evidence Sources
Biolinks for Type I IFN are extracted by users from 4 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (Type I IFN) are listed here. Abstracts are hidden.
-
2000Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2011Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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2014Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2014Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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See extended map
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Map Type I IFN to ...
NB! This is beta feature, which sometimes hangs. We are working on optimising it.
Pavel Solodkin
ranked
added it
1 year ago
on Jun 4, 2021
Do something with Type I IFN
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 8 Biolinks that connect Type I IFN with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Type I IFN
Biolinks should be proven by researches.
- There are 4 Evidences supporting 8 Type I IFN Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
Type I IFN. can be generated from biolinks.
Visualise biolinks!
- Type I IFN Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Type I IFN. and Subnodes: .
- Find Path to another object.
- Build Custom Map
Type I IFN has 4 incoming and 4 outgoing biolinks:
- Instream into nodes that connect into Type I IFN.
- Outstream from nodes that go out from Type I IFN.
- Promoters of Type I IFN
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases Type I IFN». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
Other options
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