KISS1

«Kisspeptin (including kisspeptin-54, formerly known as metastin) are proteins encoded by the KISS1gene in humans. Kisspeptin are ligands of the G-protein coupled receptor, GPR54.[4]Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis.[5] Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research.[6] Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitary triggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormone lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and humans. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas(wikipedia)

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Павел Солодкин ranked added it 2 weeks ago on May 26, 2021