IDO Indoleamine 2,3-Dioxygenase enzyme

«Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDOEC1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cell, such as the small intestine, lung, female genital tract or placenta.[5] In humans is encoded by the IDO1gene.[6] IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase (IDO2)[7] and tryptophan 2,3-dioxygenase (TDO).[8] IDO is an important part of the immune system and plays a part in natural defense against various pathogens.[9][10] It is produced by the cell in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance.[11] Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cell escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.[12][13][14]» (wikipedia)

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Alexander GritsayPRO ranked added it 1 year ago on Apr 1, 2021