Baicalein
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"Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum (Indian trumpetflower) and Thyme.[1] It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, a Chinese herbal supplement believed to enhance liver health."
"Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor.[2][3][4][5][6][7] It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors.[8] In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation.[7][8][9] It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora.[10][11] Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen." (wikipedia)
Baicalein penetrates BBB.
Summary on Baicalein
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Biochemistry of Baicalein
Pathways of Baicalein
Evidence Sources
Biolinks for Baicalein are extracted by users from 5 related publications.-
2009
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2007Human Cells
- Organism: In vitro
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2013
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2016Human Cells
- Organism: In vitro
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2017Systematic Review
- Organism: Mixed Organisms
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