Coffeine
Caffeine
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«Caffeine is a central nervous system (CNS) stimulant of the methylxanthineclass. It is the world's most widely consumed psychoactive drug. [...] it reversibly blocks the action of adenosine on its receptor and consequently prevents the onset of drowsiness induced by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system.
Caffeine is a bitter, white crystalline purine, a methylxanthinealkaloid, and is chemically related to the adenine and guaninebases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is found in the seeds, nuts, or leaves of a number of plants native to Africa, » (wikipedia)
«Caffeine is a central nervous system (CNS) stimulant of the methylxanthineclass.[10] It is the world's most widely consumed psychoactive drug.[11] Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. There are several known mechanisms of action to explain the effects of caffeine. The most prominent is that it reversibly blocks the action of adenosine on its receptors and consequently prevents the onset of drowsiness induced by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system.» (wikipedia)
Summary on Caffeine
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Biochemistry of Coffeine
Pathways of Caffeine
Caffeine Biolinks
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2.3Perhaps, Beetroot negatively interfere with Caffeine(BioMindmap Proof Quality is Low.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for Caffeine are extracted by users from 51 related publications.-
1999
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2008Cohort
- Dose: ≥4 cups of coffee/day; ≥1 cup of black tea/day
- Organism: Humans
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1988Publications Review
- Organism: Humans
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2009Meta-Analysis
- Dose: 4.1–6.0 cups of coffee/day; for >5.0 cups of tea/day
- Organism: Humans
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2002RCT
- Dose: 200-300 mg
- Organism: Humans
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2005Meta-Analysis
- Organism: Humans
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2002Cohort
- Organism: Humans
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2008RCT
- Dose: up to 400 mg/day
- Organism: Humans
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2004Meta-Analysis
- Organism: Humans
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2008Bacteria
- Organism: Fungus
- Notable Magnitude of Effect.
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2009Expert Opinion
- Organism: Humans
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2010Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2010Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2015Systematic Review
- Organism: Humans
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2016Meta-Analysis
- Organism: Humans
- Strong Magnitude of Effect.
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1983
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2009
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2012RCT
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2014
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2015Cohort
- Notable Magnitude of Effect.
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2015Systematic Review
- Organism: Humans
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2015
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2016Non Random CT
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2017Cohort
- Dose: >= 3 cups/day
- Condition: in korean population
- Organism: Humans
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2018
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2018
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2002
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2003
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2004
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2004Non Random CT
- Dose: 7mg/kg
- Minor Magnitude of Effect.
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2006
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2010
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2010
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2010
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2010
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2010
- Condition: for extraverts
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1990
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2013Meta-Analysis
- Organism: Humans
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2014Meta-Analysis
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- From this research we know that
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2.3Perhaps, Beetroot negatively interfere with Caffeine(BioMindmap Proof Quality is Low.) (BioMindmap had flagged this statement.)
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2015Meta-Analysis
- Organism: Humans
- Notable Magnitude of Effect.
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2015
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2017
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2017
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2019Meta-Analysis
- Condition: in sleep deprived/restricted individuals
- Organism: Humans
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1980
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1993
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2013Bacteria
- Organism: Fungus
- Notable Magnitude of Effect.
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2015Insects
- Organism: Nematode
- Notable Magnitude of Effect.
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This screen hints what BioMindmap can do with medical objects
- See 62 Biolinks that connect Caffeine with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Caffeine
- There are 51 Evidences supporting 62 Caffeine Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
- Caffeine Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Caffeine. and Subnodes: .
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- Instream into nodes that connect into Caffeine.
- Outstream from nodes that go out from Caffeine.
- Promoters of Caffeine
- Add biolink i.e. «X increases Caffeine». Intuitively easy.
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