Glutathione
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Glutathione (GSH), a tripeptide consisting of glutamate, cysteine
and glycine is the key regulator of the intracellular redox state. It can
non-enzymatically detoxify ROS, such as superoxide and hydroxyl
radicals, as well as act as an electron donor for the reduction of
peroxides, catalysed by glutathione peroxidase
«Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxide, and heavy metals.[2] It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamateside chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by normal peptide linkage to a glycine.
Thiol groups are reducing agents, existing at a concentration around 5 mM in animal cell. Glutathione reduces disulfide bonds formed within cytoplasmicproteins to cysteine by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also called L-(–)-glutathione.
Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor.[3] The ratio of reduced glutathione to oxidized glutathione within cell is often used as a measure of cellular oxidative stress.[4][5]» (wikipedia)
Summary on Glutathione
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Sources of Glutathione
Pathways of Glutathione
Glutathione Biolinks
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0.5Perhaps, Black Cumin Oil increases Glutathione(BioMindmap Proof Quality is Very Light.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for Glutathione are extracted by users from 43 related publications.- Organism: Humans
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2008RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2008RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2011RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2008RCT
- Organism: Humans
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2009Non Random CT
- Organism: Humans
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2007
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2013RCT
- Organism: Humans
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2014RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2014RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2017Publications Review
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2018Cohort
- Organism: Humans
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2018RCT
- Organism: Humans
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2019Systematic Review
- Organism: Humans
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2020Systematic Review
- Organism: Humans
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2019Publications Review
- Organism: Humans
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2008
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- From this research we know that
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0.5Perhaps, Black Cumin Oil increases Glutathione(BioMindmap Proof Quality is Very Light.) (BioMindmap had flagged this statement.)
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2013
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2016RCT
- Organism: Humans
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2017
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2018
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1999
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2000
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- From this research we know that
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0.5Perhaps, Black Cumin Oil increases Glutathione(BioMindmap Proof Quality is Very Light.) (BioMindmap had flagged this statement.)
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2003
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2005
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1992
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1992
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2005
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2010
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2013Rodents
- Organism: Mouse / Rat (Rodents)
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2013
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2015
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2015
- Organism: Mouse / Rat (Rodents)
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- From this research we know that
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0.5Perhaps, Black Cumin Oil increases Glutathione(BioMindmap Proof Quality is Very Light.) (BioMindmap had flagged this statement.)
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2016
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2017
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2018
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2019Systematic Review
- Organism: Humans
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2017Systematic Review
- Organism: Mixed Organisms
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- See 43 Biolinks that connect Glutathione with other objects
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- Summarize how other objects relate to Glutathione
- There are 43 Evidences supporting 43 Glutathione Biolinks
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Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
- Glutathione Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
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- Promoters of Glutathione
- Add biolink i.e. «X increases Glutathione». Intuitively easy.
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