Oxidative stress
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«Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cell can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive oxygen species (ROS) generated, e.g. O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide).[1] Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.
In humans, oxidative stress is thought to be involved in the development of ADHD,[2]cancer,[3]Parkinson's disease,[4]Lafora disease,[5]Alzheimer's syndrome,[6]atherosclerosis,[7]heart failure,[8]myocardial infarction,[9][10]fragile X syndrome,[11]sickle-cell disease,[12]lichen planus,[13]vitiligo,[14]autism,[15]infection, chronic fatigue syndrome,[16] and depression[17] and seems to be characteristic of individuals with Asperger syndrome.[18] However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens.[19] Short-term oxidative stress may also be important in prevention of aging by induction of a process name mitohormesis.[20]» (wikipedia)
Summary on Oxidative stress
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Causes of Oxidative stress
Prevention of Oxidative stress
Pathways of Oxidative stress
Oxidative stress Biolinks
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-1.7Perhaps, Oxidative stress causes AD(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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-2.1Perhaps, Oxidative stress lowers PGC-1α(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for Oxidative stress are extracted by users from 66 related publications.- From this research we know that
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-2.1Perhaps, Oxidative stress lowers PGC-1α(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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2016
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2007RCT
- Organism: Humans
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2009RCT
- Organism: Humans
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2009Cohort
- Organism: Humans
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2011RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2011RCT
- Organism: Humans
- Minor Magnitude of Effect.
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2011Cohort
- Organism: Humans
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2012RCT
- Organism: Humans
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2012RCT
- Organism: Humans
- Minor Magnitude of Effect.
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2013RCT
- Organism: Humans
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2013RCT
- Organism: Humans
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2013RCT
- Organism: Humans
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2015RCT
- Organism: Humans
- Minor Magnitude of Effect.
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2015RCT
- Organism: Humans
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2018RCT
- Organism: Humans
- Minor Magnitude of Effect.
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2019RCT
- Organism: Humans
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2019RCT
- Organism: Humans
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2017Cohort
- Organism: Humans — Not Healthy
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2015Rodents
- Condition: in rodents after traumatic brain injury (TBI)
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2005Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2007Publications Review
- Strong Magnitude of Effect.
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2009Non Random CT
- Condition: y enrolled 20 female type II diabetic subjects aged >55 years with mild-to-moderate fine lines, wrinkles and hyperpigmentation on the face and hands
- Organism: Humans — Not Healthy
- Notable Magnitude of Effect.
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2009
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2011Rodents
- Organism: Mouse / Rat (Rodents)
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2011Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2011Publications Review
- Condition: menopausal and post-menopausal women
- Organism: Females — Postmenopausal
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2012Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2012Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2014
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2017
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2019Systematic Review
- Organism: Humans
- None Magnitude of Effect.
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2019Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2020Publications Review
- Organism: Humans — Not Healthy
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2020Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2013
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2013
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2016Publications Review
- Condition: Obesity
- Organism: Humans
- Strong Magnitude of Effect.
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2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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2017Publications Review
- Strong Magnitude of Effect.
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2017Publications Review
- Strong Magnitude of Effect.
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2017
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2018
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2019RCT
- Dose: 80 mg/day
- Organism: Humans
- Minor Magnitude of Effect.
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2020Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
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2021Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2004
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2008
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2008Rodents
- Organism: Mouse / Rat (Rodents)
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2010
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2011RCT
- Organism: Humans — Not Healthy
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2012Rodents
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2013
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2013
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- From this research we know that
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-1.7Perhaps, Oxidative stress causes AD(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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2017
- Notable Magnitude of Effect.
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2017
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2019
- Organism: Mouse / Rat (Rodents)
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2019RCT
- Organism: Humans
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2019Systematic Review
- Organism: Mixed Organisms
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2019RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2019
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2020RCT
- Organism: Humans
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2020RCT
- Organism: Humans
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2017Systematic Review
- Organism: Mixed Organisms
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2007Non-human Cells
- Condition: effect shown in rat neocortical neurons subjected to glutamate excitotoxicity
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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sciencedirect.com/science/article/pii/S0306452206016617?via%3Dihub10.1016/j.neuroscience.2006.11.065
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