C-Jun N-Terminal Kinase
«c-Jun N-terminal kinase (JNKs), were originally identified as kinase that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinase kinase, MKK4 and MKK7, and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. It has been suggested that this signaling pathway contributes to inflammatory responses in mammals and insects» (wikipedia)
Do something with JNK
Lists what BioMindmap can do with its medical objects for demo purposes.
- See 10 Biolinks that connect JNK with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to JNK
- There are 10 Evidences supporting 10 JNK Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- JNK Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of JNK. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Instream into nodes that connect into JNK.
- Outstream from nodes that go out from JNK.
- Promoters of JNK
- Add biolink i.e. «X increases JNK». Intuitively easy.
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
- Ask Telegram Bot to get quick Summary on any object.