TNF-α • How it works? Researched 30 times | BioMindmap.com

Tumor Necrosis Factor Alpha TNF-α cytokine

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«Tumor necrosis factor is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophage, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cell, neutrophils, mast cell, eosinophils, and neurons.

Tumor Necrosis Factor Alpha is also known as TNFα, TNFa, cachexin, cachectin and it is a cytokine. Here is an overview of its with

Classification

Bolder font means better proofs. Alt+click opens node.

It is:

Biochemistry

↑ Increases:

↑ May increase:

↓ May decrease:

Effects

↑ Excess causes:

↓ May worsen:

Sources

→ Increased by: ,

→ May be increased by: , , , , ,

Lowering

↘ Decreased by: , , , , , , ,

↘ May be decreased by: , , , , ,

Correlation

? Affects:

Absence of Correlation

× Is not affected by:

Pathways of TNF-α

Textual paths of Biolinks with Validity Score > 3.0

Paths that increase TNF-α

Paths that decrease TNF-α

Paths that TNF-α increase

Paths that TNF-α decrease

Paths that TNF-α connect with other objects (coming soon)

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This tool shows paths like: A B C TNF-α

Mindmaps

Visualisation of logical biolinks between drugs, supplements, symptoms etc..

TNF-α Biolinks

—
Obviously TNF-α is type of Adipokines
—
Obviously sTNF-RII increases TNF-α
5.2
Boron decreases TNF-α
4.8
Panax Ginseng decreases TNF-α
4.1
Metformin decreases TNF-α
4.0
Leptin may increase TNF-α
3.3
Anthocyanins decrease TNF-α
(BioMindmap Proof Quality is Acceptable.)
3.3
Pentoxifylline lowers TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.8
Niacin does not affect TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.7
Coenzyme Q10 lowers TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
Ginger downregulates TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α increases Inflammation
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α excess causes Cancer
(BioMindmap Proof Quality is Acceptable.)
2.4
Ghrelin reduces TNF-α
(BioMindmap Proof Quality is Low.)
2.1
TNF-α associated with Frailty
(BioMindmap Proof Quality is Low.)
2.1
AGEs correlated with increased TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Niacin reduces TNF-α
(BioMindmap Proof Quality is Low.)
1.8
Alcohol increases TNF-α
(BioMindmap Proof Quality is Low.)
1.8
Diosmin lowers TNF-α
(BioMindmap Proof Quality is Low.)
1.7
TNF-α activates NF-kB
(BioMindmap Proof Quality is Low.)
1.6
Gingko Biloba lowers TNF-α
(BioMindmap Proof Quality is Low.)
1.6
TNF-α hurts Hepatocyte
(BioMindmap Proof Quality is Low.)
1.6
TNF-α inhibits Ghrelin
(BioMindmap Proof Quality is Low.)
1.6
Beta-glucans increase TNF-α
(BioMindmap Proof Quality is Low.)
1.4
Adipose tissue macrophage produces TNF-α
(BioMindmap Proof Quality is Low.)
1.0
Cat's claw inhibits TNF-α
(BioMindmap Proof Quality is Low.)
0.9
Lion's Mane may decrease TNF-α
(BioMindmap Proof Quality is Very Light.)
0.6
Perhaps, Adipose tissue secretes TNF-α
(Not proven by a research!)
-0.8
Perhaps, Sambucus spp. increases TNF-α
(BioMindmap Proof Quality is Negative.)
-1.7
Perhaps, Young plasma may decrease TNF-α
(BioMindmap Proof Quality is Negative.)

Evidence Sources

Biolinks for TNF-α are extracted by users from 30 related publications.

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