Tumor Necrosis Factor Alpha
«Tumor necrosis factor is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophage, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cell, neutrophils, mast cell, eosinophils, and neurons.
The primary role of TNF is in the regulation of immune cell. TNF, being an endogenouspyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cell. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, psoriasis and inflammatory bowel disease (IBD). Though controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancer with which excessive production is associated.» (wikipedia)
Do something with TNF-α, already
This screen hints what BioMindmap can do with medical objects
- See 49 Biolinks that connect TNF-α with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to TNF-α
- There are 63 Evidences supporting 49 TNF-α Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- TNF-α Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of TNF-α. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Instream into nodes that connect into TNF-α.
- Outstream from nodes that go out from TNF-α.
- Promoters of TNF-α
- Add biolink i.e. «X increases TNF-α». Intuitively easy.
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