TNF-α • How it works? Researched 80 times | BioMindmap.com

Tumor Necrosis Factor Alpha TNF-α cytokine

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«Tumor necrosis factor is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cell, neutrophil, mast cell, eosinophils, and neurons.

Tumor Necrosis Factor Alpha is also known as TNFα, TNFa, cachexin, cachectin and it is a cytokine. Here is an overview of its with

Classification

Bolder font means better proofs. Alt+click opens node.

It is: ,

Biochemistry

↑ Increases: , , , , ,

↑ May increase: ,

↓ Decreases:

↓ May decrease:

Effects

↑ Excess causes:

↓ May worsen:

Sources of TNF-α

→ Increased by: , , , , , , ,

→ May be increased by: , , , , , , , ,

→ Improved by:

Lowering of TNF-α

↘ Decreased by: , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

↘ May be decreased by: , , , , , , , , , , ,

Correlation

? Affects: ,

? Affected by: , ,

Absence of Correlation

× Is not affected by:

Pathways of TNF-α

Textual paths of Biolinks with Validity Score > 3.0

How to increase TNF-α?

How to decrease TNF-α?

What TNF-α increases or causes?

What TNF-α decreases?

Paths that connect TNF-α with other objects (coming soon)?

Uses in-app credits

This tool shows paths like: A B C TNF-α

Mindmaps

Visualisation of logical biolinks between drugs, supplements, symptoms etc..

TNF-α Biolinks

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Obviously TNF-α is Proinflammatory cytokine
—
Obviously TNF-α is type of Adipokines
—
Obviously sTNF-RII increases TNF-α
9.6
Berberine decreases TNF-α
+4
9.5
PUFA decreases TNF-α
9.4
Astaxanthin decreases TNF-α
+3
9.3
Depression increases TNF-α
8.7
Melatonin decreases TNF-α
8.6
Fisetin decreases TNF-α
8.2
TNF-α activates NF-kB
6.9
Th1 produces TNF-α
6.0
Apigenin decreases TNF-α
5.5
Baicalein inhibits TNF-α
5.3
NAC prevents TNF-α
5.3
TNF-α positively correlates with Endometriosis
5.3
Lactobacillus plantarum DR7 suppresses TNF-α
5.3
Obesity indirectly increases TNF-α
5.2
SOCS3 regulates TNF-α
5.2
Boron decreases TNF-α
5.0
TNF-α increases ACTH
5.0
ACE inhibitors decrease TNF-α
5.0
TNF-α increases CRH
5.0
Major depressive disorder increases TNF-α
5.0
TNF-α increases Indoleamine 2,3-Dioxygenase
5.0
TNF-α reduces Serotonin
5.0
TNF-α increases Cortisol
5.0
Bromelain decreases TNF-α
5.0
EGCG decreases TNF-α
4.8
Panax Ginseng decreases TNF-α
4.1
Leptin may increase TNF-α
4.1
Metformin decreases TNF-α
3.2
Chamomile decreases TNF-α
(BioMindmap Proof Quality is Acceptable.)
3.1
Psoriasis positively correlates with TNF-α
(BioMindmap Proof Quality is Acceptable.)
3.0
Anthocyanins decrease TNF-α
(BioMindmap Proof Quality is Acceptable.)
3.0
Pentoxifylline lowers TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.9
Chlorophyll decreases TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.9
Niacin does not affect TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.7
Coenzyme Q10 lowers TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
Ghrelin reduces TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
Ginger downregulates TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α increases Inflammation
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α excess causes Cancer
(BioMindmap Proof Quality is Acceptable.)
2.4
Progesterone increases TNF-α
(BioMindmap Proof Quality is Low.)
2.4
Glycine + NAC decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.4
Hashimoto Thyroiditis positively correlates with TNF-α
(BioMindmap Proof Quality is Low.)
2.2
Estradiol decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.2
DIM decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.2
I3C decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.2
L. casei decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.1
Testosterone decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.1
L-carnitine decreases TNF-α
(BioMindmap Proof Quality is Low.)
2.1
Eldecalcitol inhibits TNF-α
(BioMindmap Proof Quality is Low.)
2.1
Endometriosis positively correlates with TNF-α
(BioMindmap Proof Quality is Low.)
2.1
Sulforaphane inhibits TNF-α
(BioMindmap Proof Quality is Low.)
2.1
AGEs correlated with increased TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Glucose increases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Bromantane decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
LDN increases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
L. reuteri ATCC PTA 4659 decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
L. reuteri ATCC PTA 5289 decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Phytol decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Fisetin inhibits TNF-α
(BioMindmap Proof Quality is Low.)
1.9
TNF-α associated with Frailty
(BioMindmap Proof Quality is Low.)
1.9
Niacin reduces TNF-α
(BioMindmap Proof Quality is Low.)
1.8
Alcohol increases TNF-α
(BioMindmap Proof Quality is Low.)
1.7
TNF-α hurts Hepatocyte
(BioMindmap Proof Quality is Low.)
1.7
TNF-α inhibits Ghrelin
(BioMindmap Proof Quality is Low.)
1.6
SIMPL potentiates TNF-α
(BioMindmap Proof Quality is Low.)
1.6
Diosmin lowers TNF-α
(BioMindmap Proof Quality is Low.)
1.6
Gingko Biloba lowers TNF-α
(BioMindmap Proof Quality is Low.)
1.6
Beta-glucans increase TNF-α
(BioMindmap Proof Quality is Low.)
1.4
TNF-α increases JNK
(BioMindmap Proof Quality is Low.)
1.4
TNF-α increases NF-kB
(BioMindmap Proof Quality is Low.)
1.4
Adipose tissue macrophage produces TNF-α
(BioMindmap Proof Quality is Low.)
1.2
Cat's claw inhibits TNF-α
(BioMindmap Proof Quality is Low.)
0.9
Lion's Mane may decrease TNF-α
(BioMindmap Proof Quality is Very Light.)
0.6
Perhaps, Adipose tissue secretes TNF-α
(Not proven by a research!)
-0.8
Perhaps, Sambucus spp. increases TNF-α
(BioMindmap Proof Quality is Negative.)
-2.0
Perhaps, Young plasma may decrease TNF-α
(BioMindmap Proof Quality is Negative.)

Evidence Sources

Biolinks for TNF-α are extracted by users from 111 related publications.