NF-E2-related factor 2
Nrf2
metabolite
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«Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2gene.[5] Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.[6] Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.» (wikipedia)
Summary on Nrf2
NF-E2-related factor 2 is
also known as nuclear factor erythroid-2-related factor 2 and it is
a
metabolite.
Here is an overview of its
28 biolinks
with
low
average validity.
Bolder font means better proofs.
Alt+click opens node.
It is:
Antioxidants
↑ Increases:
P62, Proteasome activity
↑ May increase:
NQO1
↓ Decreases:
Oxidation
↓ May decrease:
ROS
↑ May improve:
Cancer, Neurodegeneration, Respiratory diseases
↑ May cause:
γ-glutamyl cysteine ligase
Sources of Nrf2
→ Increased by:
Astaxanthin, BMAL1, Fisetin, Spermidine, Sulforaphane
→ May be increased by:
ALA, Ashwagandha, Açaí, Bromocriptine, Calorie Restriction, Deprenyl, Falcarinol, Fluvastatin, Metformin, Resveratrol, TBHQ
→ May be improved by:
Ageing
↘ May be decreased by:
Chronic Obstructive Pulmonary Disease
Pathways of Nrf2
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C Nrf2
Evidence Sources
Biolinks for Nrf2 are extracted by users from 28 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (Nrf2) are listed here. Abstracts are hidden.
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2012Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2012Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2015
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2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2017Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2018Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2019Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2019Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2013
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2014
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2016
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2015
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2017Publications Review
- Organism: Humans
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2018
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2019
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2005
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2008
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2010
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2010
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2013
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2015
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2016Rodents
- Organism: Mouse / Rat (Rodents)
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2016Rodents
- Organism: Mouse / Rat (Rodents)
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2017
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2018
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2020Rodents
- Organism: Mouse / Rat (Rodents)
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Do something with Nrf2, already
This screen hints what BioMindmap can do with medical objects
Biolink is a statement and objects connection.
- See 28 Biolinks that connect Nrf2 with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Nrf2
Biolinks should be proven by researches.
- There are 28 Evidences supporting 28 Nrf2 Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
Nrf2. can be generated from biolinks.
Visualise biolinks!
- Nrf2 Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Nrf2. and Subnodes: .
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Nrf2 has 18 incoming and 10 outgoing biolinks:
- Instream into nodes that connect into Nrf2.
- Outstream from nodes that go out from Nrf2.
- Promoters of Nrf2
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases Nrf2». Intuitively easy.
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