Phenylalanine hydroxylase
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«Phenylalanine hydroxylase (PAH) (EC1.14.16.1) is an enzyme that catalyzes the hydroxylation of the aromatic side-chain of phenylalanine to generate tyrosine. PAH is one of three members of the biopterin-dependent aromatic amino acid hydroxylases, a class of monooxygenase that uses tetrahydrobiopterin (BH4, a pteridine cofactor) and a non-heme iron for catalysis. During the reaction, molecular oxygen is heterolytically cleaved with sequential incorporation of one oxygen atom into BH4 and phenylalanine substrate.[5]

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Summary on Phenylalanine hydroxylase

↑ May increase: Tyrosine
↓ Decreases: Dopamine, Noradrenaline, Serotonin
↓ May decrease: Phenylalanine
→ May be increased by: BH4

Pathways of Phenylalanine hydroxylase

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Biolinks for Phenylalanine hydroxylase are extracted by users from 2 related publications.
Generic SubmitterPRO ranked added it 3 years ago on Mar 15, 2020
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