TLR4

«Toll-like receptor 4 is a protein that in humans is encoded by the TLR4gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation lead to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.[4]

It is most well-known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and select Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein.[5]» (wikipedia)

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Pathways of TLR4

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