«Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.
Although it is used as a dietary supplement, there is no good evidence that consuming resveratrol affects life expectancy or human health.
There is no evidence of benefit from resveratrol in those who already have heart disease. A 2014 Chinese meta-analysis found a statistically significant 11.90 mmHg reduction in systolic blood pressure from resveratrol doses of 150 mg/day.
As of 2014[update], there is no evidence of an effect of resveratrol on cancer in humans.
There is no conclusive evidence for an effect of resveratrol on human metabolism.
There is no evidence for an effect of resveratrol on lifespan in humans as of 2011[update].
A limited number of human studies have shown resveratrol is generally well-tolerated.
A 2018 review of 17 clinical trials on the effects of resveratrol on blood pressure found that one person taking a 1000 mg daily dose developed an itchy rash that resolved after discontinuation, and that in four of the trials, people had increased frequency of bowel movements and loose stools in first month of the trial. In a year long preliminary clinical trial in people with Alzheimer's disease, the most frequent adverse effects were diarrhea, weight loss, and nausea.
Resveratrol has been identified as a pan-assay interference compound, which produces positive results in many different laboratory assays. Its ability for varied interactions may be due to direct effects on cell membranes.
As of 2015, many specific biological targets for resveratrol had been identified or identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at that time if any or all of these were responsible for the observed effects in cell and model organisms.
In vitro studies indicate resveratrol activates sirtuin 1, although this may be a downstream effect from its immediate biological target(s). It appears to signal through PGC-1α, thereby affecting mitochondria. In cell treated with resveratrol, an increase is observed in the action of MnSOD (SOD2) and in GPER activity. In vitro, resveratrol was shown to act as an agonist of Peroxisome proliferator-activated receptor gamma, a nuclear receptor under pharmacological research as a potential treatment for type 2 diabetes.
One way of administering resveratrol in humans may be buccal delivery by direct absorption through the saliva. However, the viability of a buccal delivery method is unlikely due to the low aqueous solubility of the molecule. The bioavailability of resveratrol is about 0.5% due to extensive hepaticglucuronidation and sulfation.» (wikipedia)