Adrenocorticotropic Hormone
ACTH
hormone
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«Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptidetropic hormone produced by and secreted by the anterior pituitary gland.[1] It is also used as a medication and diagnostic agent.
ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol by the cortex of the adrenal gland. ACTH is also related to the circadian rhythm in many organisms.[2]
Deficiency of ACTH is a sign of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease a pituitary tumor is the cause of elevated ACTH (from the anterior pituitary) and an excess of cortisol (hypercortisolism) – this constellation of signs and symptoms is known as Cushing's syndrome.» (wikipedia)
Summary on ACTH
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Pathways of ACTH
Evidence Sources
Biolinks for ACTH are extracted by users from 10 related publications.-
2021Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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1982
- Organism: Males
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2012Systematic Review
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1987Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2011Publications Review
- Organism: In vitro
- Notable Magnitude of Effect.
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2017Publications Review
- Organism: Mammals
- Strong Magnitude of Effect.
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2019Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2002Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2006RCT
- Organism: Males
- Notable Magnitude of Effect.
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- There are 10 Evidences supporting 18 ACTH Biolinks
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- ACTH Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
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