«Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptidetropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent.
ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol by the cortex of the adrenal gland. ACTH is also related to the circadian rhythm in many organisms.
Deficiency of ACTH is a sign of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease a pituitary tumor is the cause of elevated ACTH (from the anterior pituitary) and an excess of cortisol (hypercortisolism) – this constellation of signs and symptoms is known as Cushing's syndrome.» (wikipedia)
Do something with ACTH, already
This screen hints what BioMindmap can do with medical objects
- See 14 Biolinks that connect ACTH with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to ACTH
- There are 8 Evidences supporting 14 ACTH Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- ACTH Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of ACTH. and Subnodes: .
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- Instream into nodes that connect into ACTH.
- Outstream from nodes that go out from ACTH.
- Promoters of ACTH
- Add biolink i.e. «X increases ACTH». Intuitively easy.
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