Leptin
hormone
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«Leptin (from Greek λεπτός leptos, "thin"), "the hormone of energy expenditure",[a] is a hormone predominantly made by adipose cell that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormone act on receptors in the arcuate nucleus of the hypothalamus.[6] In obesity, a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes), resulting in an inability to detect satiety despite high energy stores and high levels of leptin.[7]
Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its many sites of synthesis other than fat cell, and the many cell types beside hypothalamic cell that have leptin receptors. Many of these additional functions are yet to be defined.[8][9][10][11][12][13]» (wikipedia)
Summary on Leptin
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Biochemistry of Leptin
Effects of Leptin
Sources of Leptin
Correlation of Leptin
Pathways of Leptin
Leptin Biolinks
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-0.8Perhaps, Leptin negatively correlates with FSH(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for Leptin are extracted by users from 35 related publications.-
1998
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2006Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2018Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2020Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2008Publications Review
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2008Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2012
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2013Rodents
- Organism: Mouse / Rat (Rodents)
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2014Cohort
- Condition: healthy, regularly menstruating, premenopausal women
- Organism: Females — Premenopausal
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- From this research we know that
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-0.8Perhaps, Leptin negatively correlates with FSH(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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2011Monkeys
- Organism: Monkey / Ape
- Notable Magnitude of Effect.
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2014Systematic Review
- Organism: Humans
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2015Publications Review
- Organism: Humans
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2015Systematic Review
- Organism: Humans
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2016Cohort
- Condition: women with eating disorders
- Organism: Females
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2016Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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2018Cohort
- Organism: Humans — Not Healthy
- Strong Magnitude of Effect.
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2018Systematic Review
- Organism: Humans
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2018Meta-Analysis
- Organism: Humans
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2018Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2018Publications Review
- Organism: Humans
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1999
- Organism: In vitro
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2002Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2002RCT
- Condition: spontaneous autoimmunity, the non-obese diabetic female mouse
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2004Publications Review
- Organism: Humans
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2006RCT
- Dose: 1500 mg
- Condition: Metabolic syndrome
- Organism: Humans
- Notable Magnitude of Effect.
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2006Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2006Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2008
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2016
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2018
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2018Systematic Review
- Organism: Humans
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2019Cohort
- Organism: Humans
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2000Cohort
- Condition: eating disorder patients
- Organism: Females
- Notable Magnitude of Effect.
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1999Cohort
- Organism: Females
- Notable Magnitude of Effect.
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- See 96 Biolinks that connect Leptin with other objects
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- Summarize how other objects relate to Leptin
- There are 35 Evidences supporting 96 Leptin Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
- Leptin Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Leptin. and Subnodes: .
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- Promoters of Leptin
- Add biolink i.e. «X increases Leptin». Intuitively easy.
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