Liver Fibrosis
disease
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«Fibrosis is the formation of an abnormally large amount of scar tissue in the liver. It occurs when the liver attempts to repair and replace damaged cell. Many conditions can damage the liver. Fibrosis itself causes no symptoms, but severe scarring can result in cirrhosis, which can cause symptoms.»
Summary on Liver Fibrosis
It is
also known as hepatic fibrogenesis and it is
a
disease.
Here is an overview of its
45 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
↑ May cause:
Liver cancer, Liver cirrhosis, Liver failure
→ Caused by:
CB1, Chronic Inflammation, Liver cirrhosis, NLRP3, NOX1, Oxidative stress
→ May be caused by:
TGFβ1
Prevention of Liver Fibrosis
↘ Cured by:
Candesartan, Corticosteroid, Cyclosporine A + Corticosteroid, Dapagliflozin, Entecavir, Lamivudine, Losartan, Obeticholic acid, Peginterferon, Peginterferon + ribavirin, Pentoxifylline, Pioglitazone, Tenofovir, Ursodeoxycholic Acid
↘ May be decreased by:
Aspirin, Chlorophyllin
↘ May be cured by:
Aspirin, Extracellular matrix degradation, IL-1 antagonists, MMP upregulation, Ursodeoxycholic Acid
? Affected by:
Alcoholic liver disease, Chronic viral hepatitis, IL-17A, Liver damage, Nonalcoholic steatohepatitis
× Is not affected by:
Farglitazar, Gilbert's Syndrome, Rosiglitazone, Ursodeoxycholic Acid
Pathways of Liver Fibrosis
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C Liver Fibrosis
Evidence Sources
Biolinks for Liver Fibrosis are extracted by users from 20 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (Liver Fibrosis) are listed here. Abstracts are hidden.
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2008Cohort
- Organism: Humans — Not Healthy
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2003Cohort
- Organism: Humans — Not Healthy
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2004Rodents
- Organism: Mouse / Rat (Rodents)
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-
2005Human Cells
- Organism: In vitro
-
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2006Cohort
- Organism: Humans — Not Healthy
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-
2014
-
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2014Cohort
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2018Publications Review
-
-
2019Publications Review
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019RCT
- Organism: Humans
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-
2019Publications Review
- Organism: Humans — Not Healthy
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-
2019Publications Review
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
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2019Cohort
- Strong Magnitude of Effect.
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-
2015
-
-
2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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-
2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019
-
-
2010
-
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Do something with Liver Fibrosis
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 45 Biolinks that connect Liver Fibrosis with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Liver Fibrosis
Biolinks should be proven by researches.
- There are 20 Evidences supporting 45 Liver Fibrosis Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
Liver Fibrosis. can be generated from biolinks.
Visualise biolinks!
- Liver Fibrosis Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Liver Fibrosis. and Subnodes: .
- Find Path to another object.
- Build Custom Map
Liver Fibrosis has 42 incoming and 3 outgoing biolinks:
- Instream into nodes that connect into Liver Fibrosis.
- Outstream from nodes that go out from Liver Fibrosis.
- Promoters of Liver Fibrosis
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases Liver Fibrosis». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
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