«Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is distantly related to hemoglobin which is the iron- and oxygen-binding protein in blood, specifically in the red blood cell. In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.
Myoglobin is the primary oxygen-carrying pigment of muscle tissues. High concentration of myoglobin in muscle cell allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscle with particularly high abundance of myoglobin. Myoglobin is found in Type I muscle, Type II A and Type II B, but most texts consider myoglobin not to be found in smooth muscle.
Myoglobin was the first protein to have its three-dimensional structure revealed by X-ray crystallography. This achievement was reported in 1958 by John Kendrew and associates. For this discovery, John Kendrew shared the 1962 Nobel Prize in chemistry with Max Perutz. Despite being one of the most studied proteins in biology, its physiological function is not yet conclusively established: mice genetically engineered to lack myoglobin can be viable and fertile but show many cellular and physiological adaptations to overcome the loss. Through observing these changes in myoglobin-deplete mice, it is hypothesised that myoglobin function relates to increased oxygen transport to muscle, oxygen storage and as a scavenger of reactive oxygen species.
In humans myoglobin is encoded by the MBgene.
Myoglobin can take the forms oxymyoglobin (MbO2), carboxymyoglobin (MbCO), and metmyoglobin (met-Mb), analogously to hemoglobin taking the forms oxyhemoglobin (HbO2), carboxyhemoglobin (HbCO), and methemoglobin (met-Hb).» (wikipedia)
Do something with Myoglobin
Lists what BioMindmap can do with its medical objects for demo purposes.
- See 4 Biolinks that connect Myoglobin with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Myoglobin
- There are 4 Evidences supporting 4 Myoglobin Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- Myoglobin Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Myoglobin. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Instream into nodes that connect into Myoglobin.
- Outstream from nodes that go out from Myoglobin.
- Promoters of Myoglobin
- Add biolink i.e. «X increases Myoglobin». Intuitively easy.
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
- Ask Telegram Bot to get quick Summary on any object.