NOD-like receptor 3
NLRP3
inflammasome
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Track
My Medkit
My Symptoms
My Goals
Summary on NLRP3
NOD-like receptor 3 is
also known as NACHT, LRR and PYD domains-containing protein 3 (NALP3); cryopyrin and it is
an
inflammasome.
Our overview of this inflammasome is quite short so far, as we are still gathering information.
Bolder font means better proofs.
Alt+click opens node.
↑ Increases:
IL-1β
↑ May improve:
Ageing
→ Increased by:
Atherosclerosis, oxLDL
↘ Decreased by:
Apigenin, Astaxanthin, Berberine, Berberine, Melatonin, β-hydroxybutyrate
Pathways of NLRP3
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C NLRP3
Evidence Sources
Biolinks for NLRP3 are extracted by users from 14 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (NLRP3) are listed here. Abstracts are hidden.
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2013
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2015Rodents
- Organism: Mouse / Rat (Rodents)
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2016Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2019Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2019Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2020Human Cells
- Organism: In vitro
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2020Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2020Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2015
- Notable Magnitude of Effect.
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2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2013
- Notable Magnitude of Effect.
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2018Systematic Review
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See extended map
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Map NLRP3 to ...
NB! This is beta feature, which sometimes hangs. We are working on optimising it.
Do something with NLRP3, already
This screen hints what BioMindmap can do with medical objects
Biolink is a statement and objects connection.
- See 10 Biolinks that connect NLRP3 with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to NLRP3
Biolinks should be proven by researches.
- There are 14 Evidences supporting 10 NLRP3 Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
NLRP3. can be generated from biolinks.
Visualise biolinks!
- NLRP3 Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of NLRP3. and Subnodes: .
- Find Path to another object.
- Build Custom Map
NLRP3 has 8 incoming and 2 outgoing biolinks:
- Instream into nodes that connect into NLRP3.
- Outstream from nodes that go out from NLRP3.
- Promoters of NLRP3
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases NLRP3». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
Other options
- Ask Telegram Bot to get quick Summary on any object.
BioMindmap is made with Love and Science to be intuitively clear.