«Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney, thereby indirectly influencing water retention or loss, blood pressure and blood volume. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease. Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.
Aldosterone is part of the renin–angiotensin–aldosterone system. It has a plasma half-life of under 20 minutes. Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase retention of potassium. In other words, these drugs stimulate the excretion of sodium and water in urine, while they block the excretion of potassium.
Another example is spironolactone, a potassium-sparing diuretic of the steroidalspirolactone group, which decreases blood pressure by releasing fluid from the body while retaining potassium.
Aldosterone was first isolated by Simpson and Tait in 1953.» (wikipedia)
Do something with Aldosterone
Lists what BioMindmap can do with its medical objects for demo purposes.
- See 15 Biolinks that connect Aldosterone with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to Aldosterone
- There are 9 Evidences supporting 15 Aldosterone Biolinks
Guide for Good Sources list of respected domains.
The ValidityScore showsthe quality of evidences, with max 9.9.
- Aldosterone Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of Aldosterone. and Subnodes: .
- Find Path to another object.
- Build Custom Map
- Instream into nodes that connect into Aldosterone.
- Outstream from nodes that go out from Aldosterone.
- Promoters of Aldosterone
- Add biolink i.e. «X increases Aldosterone». Intuitively easy.
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