IL-1β
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«Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other name, is a cytokineprotein that in humans is encoded by the IL1Bgene.[5][6][7][8] There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.» (wikipedia)
Summary on IL-1β
Bolder font means better proofs.
Alt+click opens node.
↑ Increases:
IL-6
↓ May decrease:
ACE2
↑ Causes:
Atherogenesis
→ May be increased by:
AGEs, Gilbert's Syndrome
↘ Decreased by:
Canakinumab, Yoga
↘ May be decreased by:
Gilbert's Syndrome, Ketogenic Diet, Metformin, β-hydroxybutyrate
? Affected by:
Diabetes Type 2
Pathways of IL-1β
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C IL-1β
Evidence Sources
Biolinks for IL-1β are extracted by users from 9 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (IL-1β) are listed here. Abstracts are hidden.
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2013
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2014Human Cells
- Organism: Humans
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2014RCT
- Organism: Humans
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2015Rodents
- Organism: Mouse / Rat (Rodents)
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2013Rodents
- Condition: «mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice»
- Organism: Mouse / Rat (Rodents)
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2016
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2013
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2017Human Cells
- Organism: In vitro
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2018Systematic Review
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Biolink is a statement and objects connection.
- See 14 Biolinks that connect IL-1β with other objects
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- Summarize how other objects relate to IL-1β
Biolinks should be proven by researches.
- There are 9 Evidences supporting 14 IL-1β Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
IL-1β. can be generated from biolinks.
Visualise biolinks!
- IL-1β Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of IL-1β. and Subnodes: .
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IL-1β has 11 incoming and 3 outgoing biolinks:
- Instream into nodes that connect into IL-1β.
- Outstream from nodes that go out from IL-1β.
- Promoters of IL-1β
When you read PubMed research organise your findings here.
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