Interleukin 1 Beta
IL-1β
cytokine
Favourite
Track
My Medkit
My Symptoms
My Goals
Favourite
Track
My Medkit
My Symptoms
My Goals
«Interleukin 1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other name, is a cytokineprotein that in humans is encoded by the IL1Bgene.[5][6][7][8] There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.» (wikipedia)
Summary on IL-1β
Interleukin 1 Beta is
also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor, Interleukin 1β, IL-1beta and it is
a
cytokine.
Here is an overview of its
46 biolinks
with
acceptable
average validity.
Bolder font means better proofs.
Alt+click opens node.
It is:
Proinflammatory cytokines
↑ Increases:
Indoleamine 2,3-Dioxygenase, IL-17, IL-6
↓ May decrease:
ACE2
↑ Causes:
Atherogenesis
→ Increased by:
AGEs, Major depressive disorder, Myocardial Infarction, NF-kB, NLRP3, Progesterone
→ May be increased by:
Gilbert's Syndrome, LDN
→ Improved by:
NAC
Lowering of IL-1β
↘ Decreased by:
Apigenin, Astaxanthin, Berberine, Bromelain, Canakinumab, Chamomile, DIM, EGCG, Estradiol, Fisetin, Ketogenic Diet, L. casei, L. reuteri ATCC PTA 6475, L. reuteri DSM 17938, Melatonin, Sulforaphane, Testosterone, Yoga, β-hydroxybutyrate
↘ May be decreased by:
Chlorophyllin, Gilbert's Syndrome, Metformin, Type I IFN
? Affects:
Endometriosis, Endometriosis
? Affected by:
Diabetes Type 2, Endometriosis, Hashimoto Thyroiditis
× Is not affected by:
Depression
Pathways of IL-1β
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C IL-1β
Evidence Sources
Biolinks for IL-1β are extracted by users from 65 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (IL-1β) are listed here. Abstracts are hidden.
-
2001Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2004RCT
- Dose: testosterone replacement (Sustanon 100) vs. placebo in 27 men (age, 62 +/- 9 yr)
- Organism: Humans
-
-
2005Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2006Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2008Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2008Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2010Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2011Human Cells
- Organism: In vitro
- Strong Magnitude of Effect.
-
-
2011Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
-
-
2011Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2012Rodents
- Dose: mice were immediately administered 20 mg/kg melatonin or phosphate-buffered saline subcutaneously once a day.
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
-
-
2012Human Cells
- Dose: in the absence or presence of melatonin (10, 100, 1000 μm)
- Organism: In vitro
- Strong Magnitude of Effect.
-
-
2012Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2012Publications Review
- Organism: Females
- Notable Magnitude of Effect.
-
-
2013
-
-
2013
-
-
2013Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
-
-
2014Human Cells
- Organism: Humans
-
-
2014RCT
- Organism: Humans
-
-
2015Rodents
- Organism: Mouse / Rat (Rodents)
-
-
2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2015Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2015Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2016Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2016Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2016Publications Review
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2016Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2017Meta-Analysis
- Organism: Humans
- Strong Magnitude of Effect.
-
-
2017Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2017Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2018Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2019Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019Cohort
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2019Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
-
-
2019Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2019Publications Review
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2019Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2019Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Publications Review
- Organism: Mixed Organisms
-
-
2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2021Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2021Systematic Review
- Organism: Humans
-
-
2010Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2013Rodents
- Condition: «mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice»
- Organism: Mouse / Rat (Rodents)
-
-
2015Cohort
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2016
-
-
2017Publications Review
- Organism: Mammals
- Strong Magnitude of Effect.
-
-
2017Publications Review
- Strong Magnitude of Effect.
-
-
2018Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2020Non-human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2020Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
-
2020Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
-
-
2020Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
-
-
2013
-
-
2017Human Cells
- Organism: In vitro
-
-
2018Systematic Review
-
See extended map
Login and get extended access to our features that are calculation-heavy.
Map IL-1β to ...
NB! This is beta feature, which sometimes hangs. We are working on optimising it.
Do something with IL-1β
Lists what BioMindmap can do with its medical objects for demo purposes.
Biolink is a statement and objects connection.
- See 46 Biolinks that connect IL-1β with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to IL-1β
Biolinks should be proven by researches.
- There are 65 Evidences supporting 46 IL-1β Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
A
→
B
→
C
→
IL-1β. can be generated from biolinks.
Visualise biolinks!
- IL-1β Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of IL-1β. and Subnodes: .
- Find Path to another object.
- Build Custom Map
IL-1β has 36 incoming and 10 outgoing biolinks:
- Instream into nodes that connect into IL-1β.
- Outstream from nodes that go out from IL-1β.
- Promoters of IL-1β
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases IL-1β». Intuitively easy.
Become better
- Power-start: watch the Intro Video and Guide in Help Center
- Users improve Reputation by getting experienced and validated.
Other options
- Ask Telegram Bot to get quick Summary on any object.
BioMindmap is made with Love and Science to be intuitively clear.