Inflammation
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«Inflammation (from Latin: inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cell, or irritants,[1] and is a protective response involving immune cell, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cell and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.
The five classical signs of inflammation are heat, pain, redness, swelling, and loss of function (Latin calor, dolor, rubor, tumor, and functio laesa).[1] Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.[2] Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). Inflammation is therefore normally closely regulated by the body.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cell within the injured tissue. Prolonged inflammation, known as chronic inflammation, lead to a progressive shift in the type of cell present at the site of inflammation, such as mononuclear cell, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.
Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be. But because of how often the two are correlated, words ending in the suffix -itis (which refers to inflammation) are sometimes informally described as referring to infection. For example, the word urethritis strictly means only "urethral inflammation", but clinical health care providers usually discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis.
It is useful to differentiate inflammation and infection as there are many pathological situations where inflammation is not driven by microbial invasion – for example, atherosclerosis, type III hypersensitivity, trauma, and ischemia. There are also pathological situations where microbial invasion does not result in classic inflammatory response—for example, parasitosis, eosinophilia.» (wikipedia)
Summary on Inflammation
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Causes of Inflammation
Prevention of Inflammation
Pathways of Inflammation
Evidence Sources
Biolinks for Inflammation are extracted by users from 130 related publications.-
2019Rodents
- Dose: 15-30 mcg/kg
- Condition: COPD
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2010RCT
- Organism: Humans
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2017Cohort
- Organism: Humans — Not Healthy
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2009Rodents
- Organism: Mouse / Rat (Rodents)
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2000Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2004RCT
- Organism: Males
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2005
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2006Publications Review
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
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2007Publications Review
- Strong Magnitude of Effect.
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2006
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2008Publications Review
- Organism: Humans
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2009Publications Review
- Organism: Humans
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2010Cohort
- Organism: Humans
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2011Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2012Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2013Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2013Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2014RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2015Cohort
- Organism: Humans
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2015Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2016RCT
- Notable Magnitude of Effect.
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2016Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2017Cohort
- Organism: Humans
- Strong Magnitude of Effect.
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2017Publications Review
- Organism: In vitro
- Notable Magnitude of Effect.
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2017Systematic Review
- Organism: Humans
- Notable Magnitude of Effect.
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2018Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2018Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2019Publications Review
- Strong Magnitude of Effect.
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2019RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2019Systematic Review
- Organism: Humans
- Strong Magnitude of Effect.
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2019RCT
- Organism: Humans
- Notable Magnitude of Effect.
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2019Systematic Review
- Organism: Humans
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2019Cohort
- Organism: Humans
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2020Cohort
- Organism: Humans
- Strong Magnitude of Effect.
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2021Non Random CT
- Organism: Humans
- Notable Magnitude of Effect.
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2015Systematic Review
- Condition: long-term ketogenic diet
- Organism: Humans
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2019Human Cells
- Organism: In vitro
- Notable Magnitude of Effect.
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2020Human Cells
- Organism: In vitro
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- Organism: Humans
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2007Human Cells
- Organism: In vitro
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2008Publications Review
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2008Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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2003Rodents
- Organism: Mouse / Rat (Rodents)
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2011
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2015
- Notable Magnitude of Effect.
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2015
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2015
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2015
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2016
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2016
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2016Systematic Review
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2016
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2017Publications Review
- Organism: In vitro
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2017Systematic Review
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2017
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2016
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2017Publications Review
- Strong Magnitude of Effect.
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2017Publications Review
- Organism: Mammals
- Strong Magnitude of Effect.
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2017
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2017
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2017
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2017
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2018
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2018
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2018Cohort
- Organism: Humans
- Notable Magnitude of Effect.
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2018Rodents
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2018Rodents
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2017Non Random CT
- Dose: 60 mg at 21:00 h plus 10 mg at 09:00 h
- Condition: in patients with CMT1a (children 8-10 y.o.)
- Organism: Humans — Not Healthy
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2019Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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