Inflammation • How it works? Researched 38 times

Inflammation symptom Edit

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«Inflammation (from Latin: inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cell, or irritants,^[1] and is a protective response involving immune cell, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cell and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.

The five classical signs of inflammation are heat, pain, redness, swelling, and loss of function (Latin calor, dolor, rubor, tumor, and functio laesa).^[1] Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.^[2] Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). Inflammation is therefore normally closely regulated by the body.

Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cell within the injured tissue. Prolonged inflammation, known as chronic inflammation, lead to a progressive shift in the type of cell present at the site of inflammation, such as mononuclear cell, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.

Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be. But because of how often the two are correlated, words ending in the suffix -itis (which refers to inflammation) are sometimes informally described as referring to infection. For example, the word urethritis strictly means only "urethral inflammation", but clinical health care providers usually discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis.

It is useful to differentiate inflammation and infection as there are many pathological situations where inflammation is not driven by microbial invasion – for example, atherosclerosis, type III hypersensitivity, trauma, and ischemia. There are also pathological situations where microbial invasion does not result in classic inflammatory response—for example, parasitosis, eosinophilia.» (wikipedia)

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Summary on Inflammation

It is a symptom.

Biochemistry

Decreases: Klotho, Training response

Symptoms

Causes or may cause: Sarcopenia

Causes

Increased or caused by: Acetylcholine, Air pollution, CRP, D-galactose, NF-kB, Omega-6, TNF-α, β-casomorphin-7 (promotes)

May be increased or caused by: Cow's Milk

Prevention

Decreased by: Black Cumin Oil, Butyrate, Cat's claw, Cryotherapy, Curcumin, D-Limonene, Vitamin D3, Diacerein, EPA, Fisetin, Ghrelin, H2S, Hydrogen, Olive oil, Omega-3, Polyphenols, PPAR-β/δ, Resveratrol, Senolytics, Sulforaphane, β-casomorphin-7 (reduces)

Cured or improved by: Coconut oil

May be decreased by: Dipyridamole, Ketogenic diet, Magnesium

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Biolinks

6.5 Cryotherapy lowers Inflammation
5.7 Diacerein lowers Inflammation
4.9 Omega-6 increases Inflammation
4.8 Coconut oil does not prevent Inflammation
4.8 Olive oil decreases Inflammation
4.2 Resveratrol lowers Inflammation
3.8 Magnesium may lower Inflammation
3.4 Senolytics decrease Inflammation
3.4 Sulforaphane lowers Inflammation
3.1 Inflammation causes Sarcopenia
2.8 Black Cumin Oil reduces Inflammation
2.8 D-Limonene decreases Inflammation
2.2 β-casomorphin-7 promotes Inflammation
2.2 Omega-3 lowers Inflammation
2.2 CRP increases Inflammation
2.2 TNF-α increases Inflammation
2.1 Ketogenic diet may suppress Inflammation
1.8 Dipyridamole may decrease Inflammation
1.7 H2S decreases Inflammation
1.7 Inflammation decreases Training response
1.7 Cat's claw lowers Inflammation
1.6 Polyphenols decrease Inflammation
1.6 Butyrate lowers Inflammation
1.3 β-casomorphin-7 reduces Inflammation
1.3 Vitamin D3 decreases Inflammation
1.3 Fisetin lowers Inflammation
1.3 NF-kB increases Inflammation
1.3 Ghrelin lowers Inflammation
1.3 Hydrogen lowers Inflammation
1.3 Curcumin lowers Inflammation
1.3 D-galactose increases Inflammation
1.3 Acetylcholine mediates Inflammation
1.2 Cow's Milk may increase Inflammation
0 Lung Inflammation is type of Inflammation
0 PPAR-β/δ lowers Inflammation
0 Air pollution increases Inflammation
0 EPA lowers Inflammation
-1.3 Inflammation decreases Klotho

Related Sources

Biolinks knowledge for Inflammation is based on 47 related Proof-Sources.

Modified 1 year ago on Dec 30, 2018

Olga Novikova ranked added it 1 year ago on Jun 6, 2018

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Inflammation symptom Edit Favourite Track My Medkit My Symptoms My Goals

Alt+Click to open objects Summary on Inflammation