«Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinase, phosphatidylinositol-3-kinase, PI 3-kinase, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).[2] The pathway, with oncogenePIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.[3][4]» (wikipedia)

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Modified: 8 months ago on Dec 30, 2018
personOlga Novikova 9 lvl added it 1 year ago on Jun 5, 2018.