«Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinase, phosphatidylinositol-3-kinase, PI 3-kinase, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogenePIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.» (wikipedia)
Modified: 8 months ago on Dec 30, 2018
1 year ago on Jun 5, 2018.