Liver cirrhosis
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«Cirrhosis is a condition in which the liver does not function properly due to long-term damage.[1] This damage is characterized by the replacement of normal liver tissue by scar tissue.[1] Typically, the disease develops slowly over months or years.[1] Early on, there are often no symptoms.[1] As the disease worsens, a person may become tired, weak, itchy, have swelling in the lower legs, develop yellow skin, bruise easily, have fluid build up in the abdomen, or develop spider-like blood vessels on the skin.[1] The fluid build-up in the abdomen may become spontaneously infected.[1] Other serious complications include hepatic encephalopathy, bleeding from dilated veins in the esophagus or dilated stomach veins, and liver cancer.[1] Hepatic encephalopathy results in confusion and may lead to unconsciousness.[1]
Cirrhosis is most commonly caused by alcohol, hepatitis B, hepatitis C, and non-alcoholic fatty liver disease.[1][2] Typically, more than two or three alcoholic drinks per day over a number of years is required for alcoholic cirrhosis to occur.[1] Non-alcoholic fatty liver disease has a number of causes, including being overweight, diabetes, high blood fat, and high blood pressure.[1] A number of less common causes of cirrhosis include autoimmune hepatitis, primary biliary cholangitis, hemochromatosis, certain medications, and gallstone.[1] Diagnosis is based on blood testing, medical imaging, and liver biopsy.[1]
Some causes of cirrhosis, such as hepatitis B, can be prevented by vaccination.[1] Treatment partly depends on the underlying cause,[1] but the goal is often to prevent worsening and complications.[1] Avoiding alcohol is recommended in all cases of cirrhosis.[1] Hepatitis B and C may be treatable with antiviral medications.[1] Autoimmune hepatitis may be treated with steroid medications.[1]Ursodiol may be useful if the disease is due to blockage of the bile ducts.[1] Other medications may be useful for complications such as abdominal or leg swelling, hepatic encephalopathy, and dilated esophageal veins.[1] In severe cirrhosis, a liver transplant may be an option.[1]
Cirrhosis affected about 2.8 million people and resulted in 1.3 million deaths in 2015.[3][4] Of these, alcohol caused 348,000, hepatitis C caused 326,000, and hepatitis B caused 371,000.[4] In the United States, more men die of cirrhosis than women.[1] The first known description of the condition is by Hippocrates in the 5th century BCE.[5] The word cirrhosis is from Greek: κίρρωσις; kirrhosκιρρός "yellowish" and -osis (-ωσις) meaning "condition", describing the appearance of a cirrhotic liver.[6][7][8]» (wikipedia)
Summary on Liver cirrhosis
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Pathways of Liver cirrhosis
Evidence Sources
Biolinks for Liver cirrhosis are extracted by users from 35 related publications.-
2016
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2001Non Random CT
- Condition: Ten patients each with compensated or decompensated liver cirrhosis and 11 healthy volunteers were enrolled in the study
- Organism: Humans — Not Healthy
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- Organism: Humans — Not Healthy
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2016Clinical Guideline
- Condition: in Hepatitis B related liver cirrhosis patients
- Organism: Humans — Not Healthy
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1979RCT
- Dose: zinc sulfate, 0.2 g three times daily
- Condition: alcoholic liver cirrhosis
- Organism: Humans — Not Healthy
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2000RCT
- Organism: Humans — Not Healthy
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2001
- Organism: Humans
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2002Cohort
- Organism: Humans
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2004Publications Review
- Organism: Humans — Not Healthy
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1992Rodents
- Organism: Mouse / Rat (Rodents)
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2006Cohort
- Organism: Humans
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2007Rodents
- Organism: Mouse / Rat (Rodents)
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2008RCT
- Organism: Humans — Not Healthy
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2010Systematic Review
- Organism: Humans
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2018Publications Review
- Organism: Humans
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2019Publications Review
- Organism: Humans — Not Healthy
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1997RCT
- Organism: Humans — Not Healthy
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2006Clinical Guideline
- Organism: Humans — Not Healthy
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2009RCT
- Dose: 1.0 g polaprezinc
- Organism: Humans — Not Healthy
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2016Publications Review
- Condition: zinc + BCAA
- Organism: Humans — Not Healthy
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2015Publications Review
- Condition: alcoholic liver cirrhosis
- Organism: Humans — Healthy
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2009Publications Review
- Organism: Humans — Not Healthy
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2014Systematic Review
- Organism: Humans — Not Healthy
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2014Systematic Review
- Organism: Humans — Not Healthy
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2016Systematic Review
- Organism: Humans — Not Healthy
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2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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2017Systematic Review
- Organism: Mouse / Rat (Rodents)
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2018
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2016Cohort
- Organism: Humans
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2005RCT
- Organism: Humans — Not Healthy
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2007RCT
- Organism: Humans — Not Healthy
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2003Publications Review
- Organism: Humans
- Notable Magnitude of Effect.
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2014RCT
- Condition: Patients with cirrhosis who had recovered from an episode of HE during the previous month
- Organism: Humans — Not Healthy
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2010RCT
- Organism: Humans — Not Healthy
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2018Publications Review
- Organism: Humans — Not Healthy
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