Alanine Transaminase
ALT
marker
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«Alanine transaminase (ALT) is a transaminaseenzyme (EC2.6.1.2). It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues.[1] ALT is found in plasma and in various body tissues, but is most common in the liver. It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.» (wikipedia)
Summary on ALT
Alanine Transaminase is
a
marker.
Here is an overview of its
14 biolinks
with
low
average validity.
Bolder font means better proofs.
Alt+click opens node.
→ May be increased by:
Glucose, Liver damage, Titanium dioxide
↘ Decreased by:
Blueberry, Curcumin, Vitamin D3, Melatonin, Resveratrol, Taurine
↘ May be decreased by:
Artichoke, Chlorophyll, Coffee
× Does not affect:
Cholelithiasis
× Is not affected by:
Chloroquine
Pathways of ALT
Textual paths of Biolinks with
Validity Score > 3.0
This tool shows paths like:
A B C ALT
Add Biolink
ALT Biolinks
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-2.1Perhaps, Artichoke may decrease ALT(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
Evidence Sources
Biolinks for ALT are extracted by users from 14 related publications.
Users read a research at the PubMed. They understand a relation between two objects.
To organise this new finding, they add it as a new piece of information — a Biolink — a proven logical relation between objects, drugs or symptoms etc.
Any user can propose new knowledge which will be reviewed.
Proofs for biolinks of current node (ALT) are listed here. Abstracts are hidden.
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2008Non Random CT
- Dose: 2 g taurine three times per day for 3 months
- Organism: Humans
- Notable Magnitude of Effect.
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2010RCT
- Dose: en DMD patients age 12.8 +/- 0.98 yr, were treated with melatonin (60 mg at 21:00 hr plus 10 mg at 09:00 hr)
- Organism: Humans
- Strong Magnitude of Effect.
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2016Cohort
- Organism: Humans
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2019Rodents
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2020RCT
- Organism: Females
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2021Rodents
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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- Condition: if high
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2017
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2019RCT
- Dose: 80 mg/day
- Organism: Humans
- Minor Magnitude of Effect.
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2011Non Random CT
- Condition: in healthy obese men
- Organism: Humans — Healthy
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2018
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- From this research we know that
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-2.1Perhaps, Artichoke may decrease ALT(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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2020Meta-Analysis
- Organism: Humans — Not Healthy
- Notable Magnitude of Effect.
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2020RCT
- Organism: Humans — Not Healthy
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Biolink is a statement and objects connection.
- See 14 Biolinks that connect ALT with other objects
- Group Biolinks by type — promoters and inhibitors separately
- Summarize how other objects relate to ALT
Biolinks should be proven by researches.
- There are 14 Evidences supporting 14 ALT Biolinks
- See
Guide for Good Sources list of respected domains.
The ValidityScore shows the quality of evidences, with max 9.9.
Textual Paths like
X
→
B
→
C
→
ALT. can be generated from biolinks.
Visualise biolinks!
- ALT Mindmap — near connections
- Mindmap with ValidityScore 5.0 — near connections
- Mindmap of ALT. and Subnodes: .
- Find Path to another object.
- Build Custom Map
ALT has 13 incoming and 1 outgoing biolinks:
- Instream into nodes that connect into ALT.
- Outstream from nodes that go out from ALT.
- Promoters of ALT
When you read PubMed research organise your findings here.
- Add biolink i.e. «X increases ALT». Intuitively easy.
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- Power-start: watch the Intro Video and Guide in Help Center
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