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Logical relations between drugs, symptoms, etc.
Logical relations between drugs, symptoms, etc.
Filtering medical statements by publication URL
From this research we know that
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3.0Artichoke may cure Gilbert's Syndrome(BioMindmap Proof Quality is Acceptable.)updated by 1 year ago
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0.6Artichoke may decrease Cholesterol(BioMindmap Proof Quality is Very Light.)added by 1 year ago
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0.8Artichoke may decrease Triglycerides(BioMindmap Proof Quality is Very Light.)added by 1 year ago
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-2.1Perhaps, Artichoke may decrease ALT(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)added by 1 year ago
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0.6Fatty Liver may cause Liver cirrhosis(BioMindmap Proof Quality is Very Light.)added by 1 year ago
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0.6Fatty Liver may cause Hepatocellular carcinoma(BioMindmap Proof Quality is Very Light.)added by 1 year ago
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2018
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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is potentially treatable, though there are few therapeutic agents available. Artichoke leaf extract (ALE) has shown potential as a hepatoprotective agent. This study sought to determine if ALE had therapeutic utility in patients with established NAFLD. In this randomized double-blind placebo-controlled parallel-group trial, 100 subjects with ultrasound-diagnosed NAFLD were randomized to either ALE 600 mg daily or placebo for a 2-month period. NAFLD response was assessed by liver ultrasound and serological markers including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and AST to platelet ratio index (APRI) score. Ninety patients completed the study (49 ALE and 41 placebo) with no side effects reported. ALE treatment compared with placebo: Doppler sonography showed increased hepatic vein flow (p < .001), reduced portal vein diameter (p < .001) and liver size (p < .001), reduction in serum ALT (p < .001) and AST (p < .001) levels, improvement in AST/ALT ratio and APRI scores (p < .01), and reduction in total bilirubin. ALE supplementation reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentration (p = .01). This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD.
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