From this research we know that

• 4.5  

  Vitamin B12 improves Cognition

  updated by Insider BiohackerPRO 1 year ago
• 2.9  

  Vitamin B12 decreases Depression

  updated by Insider BiohackerPRO 1 year ago

   (BioMindmap Proof Quality is Acceptable.)
• 2014
  Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin.
• RESULTS: The mean duration of diabetes was 8.4 years (±5.8); mean duration of metformin use was 64.1 months (±43.2), with a mean metformin dose of 1,306 mg/day. A sufficient cobalamin level was independently associated with a decreased risk of depression (OR 0.42; 95 % CI 0.23-0.78) and better cognitive performance (β = 1.79; 95 % CI 0.07-3.52) adjusted for confounders. This indicates that cobalamin-deficient patients had a 2.4 times higher chance of depression and a 1.79 point lower cognitive performance score. HoloTCII was not associated with any outcome.
  CONCLUSIONS: Cobalamin deficiency was associated with an increased risk of depression and worse cognitive performance, while holoTCII was not. Screening for cobalamin deficiency may be warranted in diabetes patients using metformin. Physicians should consider a cobalamin deficiency in diabetes patients using metformin with a depression or cognitive decline.

• ---

  ncbi.nlm.nih.gov/pubmed/25315630

  Read 10.1007/s00592-014-0661-4
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