RESULTS: Of 70 subjects enrolled, 3 subjects were withdrawn from this study: 2 were due to adverse events of the compounds used, while 1 was by decline of the informed consent. Seven subjects who did not completed the 12-week treatment with the compounds, and 4 subjects who showed Ccr over 200 mL/min were excluded from the analyses. Thus, 56 subjects (MT group: 30; CT group: 26) were forwarded into actual data analyses.
CONCLUSIONS: A citrate preparation significantly increased urine pH levels and urinary uric acid excretion, and reduced serum uric acid levels in the subjects treated with allopurinol. This combination therapy also improved renal glomerular filtration effectively in a fraction of patients with reduced renal function. Thus, an additional use of citrate preparations with allopurinol is beneficial for the treatment of patients with hyperuricemia.