CONCLUSION: Molecules at the interface between metabolism and immunity such as leptin can either promote an optimal immune response in a balanced metabolic state or, on the other hand, reflect the inappropriate intake of nutrients and associate with abnormal immune response (Figure 3). Until recently, anti-leptin therapy was targeted towards weight regulation. After the discovery of the immune effects of leptin - particularly in inflammation - the development of new therapeutic approaches has been initiated. Many aspects of the biology of leptin remain unclear, and several mechanistic explanations are needed. Yet, the influence of leptin on immunity in relation to the metabolic status can lead to the development of novel approaches that may specifically focus on nutrition for the modulation of the immune response.
Comments:«Leptin has recently emerged as a key link between metabolic responses and inflammation. It is thought that the elevated levels of leptin in obese individuals can contribute to the low-grade chronic inflammation, on which degenerative diseases and autoimmune reactivity could possibly develop»