URL Biolinks for https://pubmed.ncbi.nlm.nih.gov/20015486

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9.3
Depression increases TNF-α
updated by Generic SubmitterPRO 6 months ago Publications Review (2014) Meta-Analysis (2010) Meta-Analysis (2017)
9.5
Depression increases IL-6
updated by Generic SubmitterPRO 7 months ago Publications Review (2014) Meta-Analysis (2010) Meta-Analysis (2009) Meta-Analysis (2017)

2010

A meta-analysis of cytokines in major depression
Results: Twenty-four studies involving unstimulated measurements of cytokines in patients meeting DSM criteria for major depression were included in the meta-analysis; 13 for tumor necrosis factor (TNF)-alpha, 9 for interleukin (IL)-1beta, 16 for IL-6, 5 for IL-4, 5 for IL-2, 4 for IL-8, 6 for IL-10, and 4 for interferon (IFN)-gamma. There were significantly higher concentration of TNF-alpha (p < .00001), weight mean difference (WMD) (95% confidence interval) 3.97 pg/mL (2.24 to 5.71), in depressed subjects compared with control subjects (438 depressed/350 nondepressed). Also, IL-6 concentration were significantly higher (p < .00001) in depressed subjects compared with control subjects (492 depressed/400 nondepressed) with an overall WMD of 1.78 pg/mL (1.23 to 2.33). There were no significant differences among depressed and nondepressed subjects for the other cytokines studied.

Conclusions: This meta-analysis reports significantly higher concentration of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects. While both positive and negative results have been reported in individual studies, this meta-analytic result strengthens evidence that depression is accompanied by activation of the IRS.
pubmed.ncbi.nlm.nih.gov/20015486
10.1016/j.biopsych.2009.09.033

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