«Results: the protective treatment with L-Carnitineattenuated the decline of sperm count and motility resulted from trazadone administration. Moreover, LC ameliorated trazadone increasedlipid peroxidation (MDA) and reduction of total thiol and catalase activity. LC modulated the elevation in tumor necrosis factor- α (TNF-α), and increased the expression of autophagy related genes Becline-1, ATG 5, ATG-12 in rattestes. Serum level of FSH, LH and total testosterone were increasedsignificantly (p < 0.001) in LC + TRZ group. Histopathological findings further supported the protective effects of LC against trazadone -induced testicular injury by increasing free sperm within the lumen of spermatogenic cell and improving testicular degeneration.»
thirty-two male Wistar rats were divided randomly into four groups (n = 8). Testicular damage was induced by oral administration of Trazadone (TRZ, 20 mg/kg/day, p.o.) for four weeks (TRZ group). l-carnitine (LC, 200 mg/kg/day, p.o.) was applied for four weeks (LC group). LC + TRZ group administered the same doses of LC and TRZ concomitantly. The control group received distilled water (as vehicle).