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«Our data suggest that CUR (curcumin) + SFN (sulparophane) and PEITC + SFN combinations could be more effective than used alone in preventing inflammation and possibly its associateddiseases including cancer.»
The major mechanism by which SFN, an electrophile, protects cells is believed to be through induction of direct and indirect antioxidant response, including up-regulation of glutathione and activation of NF-E2-related factor 2 (Nrf2)-mediated phase II enzymes and antioxidant enzymes that relieve cells from oxidant stress and carcinogenic attacks (11)
. However, its chemopreventive activity also includes other mechanisms, such as induction of cell cycle arrest and apoptotic pathways, inhibition of angiogenesis, and anti-inflammatory activity (9). Recently, SFN has been shown to enhance mammalian proteasome activity through induction of 26 S proteasome subunit PSMB5 (13). Both induction of PSMB5 and proteasome activation have been associated with antioxidant response mediated through the Keap1-Nrf2 pathway (13–16).
«Accumulating evidence from epidemiologic and clinical studies indicates that chronic inflammatory disorders harbor an increasedrisk of cancer development. Curcumin (CUR) has been strongly linked to the anti-inflammatory effect. On the other hand, isothiocyanates such as sulforaphane (SFN) and phenethyl isothiocyanate (PEITC) arestrong phase-II detoxifying/antioxidant enzymes inducer. Therefore it is interesting to see if combination of these drugs can inhibitinflammation with higher combined efficacies.»
«We report that combination of PEITC + SFN or CUR + SFN has a synergistic effect in down-regulating inflammation markers like TNF, IL-1, NO, PGE2. The synergism is probably due to the synergistic induction of phase II/antioxidant enzymes including heme-oxygenase1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1).»