5.2
ValidityScore
Valid or Invalid?
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2017Publications Review
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Hernández J, Terán-Cabanillas E -
«Moreover, SOCS3 is a key regulator of type I interferon and pro-inflammatory cytokine, such as TNF-α. We have previously shown that SOCS3 is overexpressed in people with obesity, and this overexpression is directly correlated with diminished production of type I interferon and pro-inflammatory cytokine after TLR stimulation, suggesting that SOCS3 might play a key role in inducing this aberrant response»
- Organism: Humans
- Notable Magnitude of Effect.
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#Cells, Cultured, Elí Terán-Cabanillas, Humans, Interferon Type I / antagonists &, Jesús Hernández, Leptin / physiology*, Ligands, MEDLINE, Monocytes, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Obesity / metabolism*, PubMed Abstract, Suppressor of Cytokine Signaling 3 Protein / physiology*, Toll-Like Receptors, U937 Cells, doi:10.1007/s10753-016-0452-x, inhibitors*, pmid:27704310more... -
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on Sep 19, 2021