Bromantane
decreases
TNF-α
(BioMindmap Proof Quality is Low.)
Bromantane
decreases
TNF-α
(BioMindmap Proof Quality is Low.)
1.9
ValidityScore
Valid or Invalid?
-
2011Rodents
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Durnev AD, Kovalenko LP, Seredenin SB, Tallerova AV -
«Abstract: The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-α, IL-6, IL-10, IL-1α, IL-2, IL-4, IL-5, IL-17, IFN-γ, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 μg/kg. Ladasten (bromantane) was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. Behavioral disturbances and significant increase in the concentration of TNF-α and IL-6 in blood plasma were observed 2 h after LPS treatment. Ladasten was more potent than imipramine in decreasing the content of proinflammatory cytokines TNF-α and IL-6 and preventing the development of behavioral disturbances in mice. Antiasthenic drug ladasten was shown to decrease the elevated level of proinflammatory cytokines TNF-α and IL-6 after LPS treatment. Further studies should be performed to develop new indications for the use of ladasten in adjuvant therapy of depression.»
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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#A V Tallerova, Adamantane / analogs &, Adamantane / pharmacology, Adamantane / therapeutic use, Animals, Antidepressive Agents / pharmacology*, Antidepressive Agents / therapeutic use, Cytokines / blood*, Depression / drug therapy*, Depression / immunology, Imipramine / pharmacology, Imipramine / therapeutic use, Inbred C57BL, Inflammation Mediators / blood*, L P Kovalenko, Lipopolysaccharides / pharmacology, MEDLINE, Male, Mice, Motor Activity / drug effects, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PubMed Abstract, S B Seredenin, derivatives*, doi:10.1007/s10517-011-1453-2, pmid:22803040more... -
ranked
added it
1 year ago
on Jun 3, 2021